Anti-EHMT2 Antibody (CAB19288)
- SKU:
- CAB19288
- Product type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- EHMT2
- Synonyms:
- BAT8
- Synonyms:
- C6orf30
- Synonyms:
- G9A
- Synonyms:
- GAT8
- Synonyms:
- KMT1C
- Synonyms:
- NG36
- Synonyms:
- histone-lysine N-methyltransferase EHMT2
Description
| 抗体名: | EHMT2 Rabbit mAb |
| 抗体コード: | CAB19288 |
| サイズ: | 20uL, 50uL, 100uL |
| 同義語: | EHMT2, BAT8, C6orf30, G9A, GAT8, KMT1C, NG36, histone-lysine N-methyltransferase EHMT2 |
| 申し込み: | WB, IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human EHMT2. |
| 申し込み: | WB, IHC |
| 推奨される希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | A375 |
| 免疫原: | Recombinant protein of human EHMT2. |
| 精製方法: | Affinity purification |
| 保管所: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 10919 |
| Uniprot: | Q96KQ7 |
| セルラーロケーション: | Chromosome, Nucleus |
| 計算された分子量: | 160, 170kDa |
| 観察された分子量: | 160KDa/180KDa |
| UniProt Protein Function: | EHMT2 iso4: Histone methyltransferase. Preferentially methylates 'Lys-9' of histone H3 and 'Lys-27' of histone H3 (in vitro). H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. Also methylates histone H1. Belongs to the histone-lysine methyltransferase family. Suvar3-9 subfamily. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Interacts with GFI1B, WIZ and EHMT1. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Methyltransferase, protein lysine; Amino Acid Metabolism - lysine degradation; Methyltransferase; EC 2.1.1.43 Chromosomal Location of Human Ortholog: 6p21.31 Cellular Component: nucleoplasm; intermediate filament cytoskeleton; intracellular membrane-bound organelle; nuclear chromatin; nucleus Molecular Function:protein binding; zinc ion binding; p53 binding; histone lysine N-methyltransferase activity (H3-K9 specific); protein-lysine N-methyltransferase activity; histone-lysine N-methyltransferase activity; histone lysine N-methyltransferase activity (H3-K27 specific) Biological Process: histone methylation; establishment and/or maintenance of chromatin architecture; peptidyl-lysine di-methylation; DNA methylation; negative regulation of transcription from RNA polymerase II promoter; regulation of DNA replication; histone H3-K9 methylation |
| NCBI Summary: | This gene is located in a gene cluster within the human major histocompatibility complex class III region on chromosome 6. This gene was thought to be two different genes, NG36 and G9a, adjacent to each other but recent publications show that there is only a single gene at this locus. The encoded protein is a histone methyltransferase, which may be involved in repression of transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] |
| UniProt Code: | Q96KQ7 |
| NCBI GenInfo Identifier: | 116241348 |
| NCBI Gene ID: | 10919 |
| NCBI Accession: | Q96KQ7.3 |
| UniProt Secondary Accession: | Q96KQ7,Q14349, Q5JP83, Q5JQ92, Q5JQA1, Q5JQG3, Q6PK06 Q96MH5, Q96QD0, Q9UQL8, Q9Y331, B0UZY2, |
| UniProt Related Accession: | Q96KQ7 |
| Molecular Weight: | 1210 |
| NCBI Full Name: | Histone-lysine N-methyltransferase EHMT2 |
| NCBI Synonym Full Names: | euchromatic histone-lysine N-methyltransferase 2 |
| NCBI Official Symbol: | EHMT2 |
| NCBI Official Synonym Symbols: | G9A; BAT8; GAT8; NG36; KMT1C; C6orf30 |
| NCBI Protein Information: | histone-lysine N-methyltransferase EHMT2; H3-K9-HMTase 3; G9A histone methyltransferase; HLA-B associated transcript 8; lysine N-methyltransferase 1C; ankyrin repeat-containing protein; histone H3-K9 methyltransferase 3; histone-lysine N-methyltransferase |
| UniProt Protein Name: | Histone-lysine N-methyltransferase EHMT2 |
| UniProt Synonym Protein Names: | Euchromatic histone-lysine N-methyltransferase 2; HLA-B-associated transcript 8; Histone H3-K9 methyltransferase 3; H3-K9-HMTase 3; Lysine N-methyltransferase 1C; Protein G9a |
| UniProt Gene Name: | EHMT2 |
| UniProt Entry Name: | EHMT2_HUMAN |