Anti-EHBP1 Antibody (CAB9286)
- SKU:
- CAB9286
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-EHBP1 Antibody |
| 抗体コード: | CAB9286 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human EHBP1 (NP_056067.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | 293T, Jurkat, LO2, Mouse brain, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human EHBP1 (NP_056067.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MASV WKRL QRVG KHAS KFQF VASY QELM VECT KKWQ PDKL VVVW TRRS RRKS SKAH SWQP GIKN PYRG VVVW PVPE NIEI TVTL FKDP HAEE FEDK EWTF |
| 遺伝子ID: | 23301 |
| Uniprot: | Q8NDI1 |
| セルラーロケーション: | Cytoplasm, Membrane |
| 計算された分子量: | 132kDa/136kDa/140kDa |
| 観察された分子量: | 180kDa |
| 同義語: | EHBP1, HPC12, NACSIN |
| バックグラウンド: | This gene encodes an Eps15 homology domain binding protein. The encoded protein may play a role in endocytic trafficking. A single nucleotide polymorphism in this gene is associated with an aggressive form of prostate cancer. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | EHBP1: May play a role in actin reorganization. Links clathrin- mediated endocytosis to the actin cytoskeleton. Defects in EHBP1 are a cause of susceptibility to prostate cancer hereditary type 12 (HPC12). It is a condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 2p15 Cellular Component: cytoplasm; plasma membrane Disease: Prostate Cancer, Hereditary, 12 |
| NCBI Summary: | This gene encodes an Eps15 homology domain binding protein. The encoded protein may play a role in endocytic trafficking. A single nucleotide polymorphism in this gene is associated with an aggressive form of prostate cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010] |
| UniProt Code: | Q8NDI1 |
| NCBI GenInfo Identifier: | 217330570 |
| NCBI Gene ID: | 23301 |
| NCBI Accession: | NP_001136086.1 |
| UniProt Secondary Accession: | Q8NDI1,O94977, Q53TG7, Q53TV6, Q580X2, Q6NX72, Q6PIT3 Q6QNV2, Q9NWI9, |
| UniProt Related Accession: | Q8NDI1 |
| Molecular Weight: | Calculated MW: 140kDaMolecular Weight: 1231 |
| NCBI Full Name: | EH domain-binding protein 1 isoform 2 |
| NCBI Synonym Full Names: | EH domain binding protein 1 |
| NCBI Official Symbol: | EHBP1 |
| NCBI Official Synonym Symbols: | HPC12; NACSIN |
| NCBI Protein Information: | EH domain-binding protein 1 |
| UniProt Protein Name: | EH domain-binding protein 1 |
| Protein Family: | EH domain-binding protein |
| UniProt Gene Name: | EHBP1 |
| UniProt Entry Name: | EHBP1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using EHBP1 antibody (CAB9286) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s. |
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