Anti-EFS Antibody (CAB16479)
- SKU:
- CAB16479
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-EFS Antibody |
| 抗体コード: | CAB16479 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-190 of human EFS (NP_115835.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse |
| ポジティブサンプル: | Mouse thymus |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-190 of human EFS (NP_115835.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | TALR VPSS GPYD CPAS FSHP LTRV APQP PGED DAPY DVPL TPKP PAEL EPDL EWEG GREP GPPI YAAP SNLK RASA LLNL YEAP EELL ADGE GGGT DEGI YDVP LLGP EAPP SPEP PGAL ASHD QDTL AQL |
| 遺伝子ID: | 10278 |
| Uniprot: | O43281 |
| セルラーロケーション: | |
| 計算された分子量: | 40kDa/48kDa/58kDa |
| 観察された分子量: | 75kDa |
| 同義語: | EFS, CAS3, CASS3, EFS1, EFS2, HEFS, SIN |
| バックグラウンド: | The longest protein isoform encoded by this gene contains an SH3 domain, which is known to be important in intracellular signal transduction. The protein encoded by a similiar gene in mice was shown to bind to SH3 domains of protein-tyrosine kinases. The function of this gene is unknown. Three alternatively spliced variants encoding different isoforms have been described for this gene. |
| UniProt Protein Function: | EFS: Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May serve as an activator of SRC and a downstream effector. Interacts with the SH3 domain of FYN and with CRK, SRC, and YES. Belongs to the CAS family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Adaptor/scaffold Chromosomal Location of Human Ortholog: 14q11.2 Cellular Component: cytoplasm Molecular Function:protein binding; protein domain specific binding |
| NCBI Summary: | The longest protein isoform encoded by this gene contains an SH3 domain, which is known to be important in intracellular signal transduction. The protein encoded by a similiar gene in mice was shown to bind to SH3 domains of protein-tyrosine kinases. The function of this gene is unknown. Three alternatively spliced variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2013] |
| UniProt Code: | O43281 |
| NCBI GenInfo Identifier: | 8134421 |
| NCBI Gene ID: | 10278 |
| NCBI Accession: | O43281.1 |
| UniProt Secondary Accession: | O43281,O43282, B2RAJ7, B4DJ56, E9PGU2, |
| UniProt Related Accession: | O43281 |
| Molecular Weight: | 40,957 Da |
| NCBI Full Name: | Embryonal Fyn-associated substrate |
| NCBI Synonym Full Names: | embryonal Fyn-associated substrate |
| NCBI Official Symbol: | EFS |
| NCBI Official Synonym Symbols: | SIN; CAS3; EFS1; EFS2; HEFS; CASS3 |
| NCBI Protein Information: | embryonal Fyn-associated substrate |
| UniProt Protein Name: | Embryonal Fyn-associated substrate |
| UniProt Synonym Protein Names: | Cas scaffolding protein family member 3 |
| Protein Family: | Embryonal Fyn-associated substrate |
| UniProt Gene Name: | EFS |
| UniProt Entry Name: | EFS_HUMAN |
 | Western blot analysis of extracts of mouse thymus, using EFS antibody (CAB16479) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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