Anti-Dynein intermediate chain 1 Antibody (CAB3624)

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SKU:
CAB3624
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CILD1
Synonyms:
DIC1
Synonyms:
ICS1
Synonyms:
PCD
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Description

抗体名:Dynein intermediate chain 1 Rabbit mAb
抗体コード:CAB3624
サイズ:20uL, 50uL, 100uL
同義語:CILD1, DIC1, ICS1, PCD
申し込み:WB
反応性:Mouse, Rat
宿主種:Rabbit
免疫原:A synthesized peptide derived from human Dynein intermediate chain 1
申し込み:WB
推奨される希釈:WB 1:500 - 1:2000
反応性:Mouse, Rat
ポジティブサンプル:Mouse lung, Mouse testis, Rat testis
免疫原:A synthesized peptide derived from human Dynein intermediate chain 1
精製方法:Affinity purification
保管所:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:Email for sequence
遺伝子ID:27019
Uniprot:Q9UI46
計算された分子量:79kDa
観察された分子量:79KDa
UniProt Protein Function:DNAI1: Part of the dynein complex of respiratory cilia. Defects in DNAI1 are the cause of primary ciliary dyskinesia type 1 (CILD1). CILD1 is an autosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. Defects in DNAI1 are the cause of Kartagener syndrome (KTGS). KTGS is an autosomal recessive disorder characterized by the association of primary ciliary dyskinesia with situs inversus. Clinical features include recurrent respiratory infections, bronchiectasis, infertility, and lateral transposition of the viscera of the thorax and abdomen. The situs inversus is most often total, although it can be partial in some cases (isolated dextrocardia or isolated transposition of abdominal viscera). Belongs to the dynein intermediate chain family.
UniProt Protein Details:

Protein type:Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 9p13.3

Cellular Component: cilium; cytoskeleton

Molecular Function:protein binding

Biological Process: determination of left/right symmetry; sperm motility

Disease: Ciliary Dyskinesia, Primary, 1

NCBI Summary:This gene encodes a member of the dynein intermediate chain family. The encoded protein is part of the dynein complex in respiratory cilia. The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia and Kartagener syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniProt Code:Q9UI46
NCBI GenInfo Identifier:12643888
NCBI Gene ID:27019
NCBI Accession:Q9UI46.1
UniProt Secondary Accession:Q9UI46,Q5T8G7, Q8NHQ7, Q9UEZ8, B7Z7U1,
UniProt Related Accession:Q9UI46
Molecular Weight:79kDa
NCBI Full Name:Dynein intermediate chain 1, axonemal
NCBI Synonym Full Names:dynein axonemal intermediate chain 1
NCBI Official Symbol:DNAI1  
NCBI Official Synonym Symbols:PCD; DIC1; ICS1; CILD1  
NCBI Protein Information:dynein intermediate chain 1, axonemal
UniProt Protein Name:Dynein intermediate chain 1, axonemal
UniProt Synonym Protein Names:Axonemal dynein intermediate chain 1
Protein Family:Dynein
UniProt Gene Name:DNAI1  
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