Anti-DUSP9 Antibody (CAB3839)
- SKU:
- CAB3839
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-DUSP9 Antibody |
抗体コード: | CAB3839 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant protein of human DUSP9 |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:200 - 1:2000 IHC 1:20 - 1:200 IF 1:20 - 1:100 |
反応性: | Human, Mouse |
ポジティブサンプル: | HeLa, HepG2, Mouse liver |
免疫原: | Recombinant protein of human DUSP9 |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 1852 |
Uniprot: | Q99956 |
セルラーロケーション: | Cytoplasm |
計算された分子量: | 41kDa |
観察された分子量: | 41kDa |
同義語: | DUSP9, MKP-4, MKP4 |
バックグラウンド: | The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases and is localized to the cytoplasm and nucleus. Aberrant expression of this gene is associated with type 2 diabetes and cancer progression in several cell types. Alternate splicing results in multiple transcript variants. |
UniProt Protein Function: | DUSP9: a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (ERK, JNK, p38). Shows selectivity for members of the ERK family, is expressed at high levels in placenta, kidney, and fetal liver, and is localized to the cytoplasm and nucleus. |
UniProt Protein Details: | Protein type:Protein phosphatase, dual-specificity; Motility/polarity/chemotaxis; EC 3.1.3.48; EC 3.1.3.16 Chromosomal Location of Human Ortholog: Xq28 Cellular Component: cytoplasm; nucleus Molecular Function:protein binding; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; phosphoprotein phosphatase activity Biological Process: JNK cascade; protein amino acid dephosphorylation; inactivation of MAPK activity |
NCBI Summary: | The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases, is expressed only in placenta, kidney, and fetal liver, and is localized to the cytoplasm and nucleus. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q99956 |
NCBI GenInfo Identifier: | 3913541 |
NCBI Gene ID: | 1852 |
NCBI Accession: | Q99956.1 |
UniProt Secondary Accession: | Q99956,D3DWU5, |
UniProt Related Accession: | Q99956 |
Molecular Weight: | 384 |
NCBI Full Name: | Dual specificity protein phosphatase 9 |
NCBI Synonym Full Names: | dual specificity phosphatase 9 |
NCBI Official Symbol: | DUSP9 |
NCBI Official Synonym Symbols: | MKP4; MKP-4 |
NCBI Protein Information: | dual specificity protein phosphatase 9; map kinase phosphatase 4; serine/threonine specific protein phosphatase; mitogen-activated protein kinase phosphatase 4 |
UniProt Protein Name: | Dual specificity protein phosphatase 9 |
UniProt Synonym Protein Names: | Mitogen-activated protein kinase phosphatase 4; MAP kinase phosphatase 4; MKP-4 |
Protein Family: | Dual specificity protein phosphatase |
UniProt Gene Name: | DUSP9 |
UniProt Entry Name: | DUS9_HUMAN |
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