Anti-DUSP5 Antibody (CAB10212)
- SKU:
- CAB10212
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-DUSP5 Antibody |
抗体コード: | CAB10212 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 315-384 of human DUSP5 (NP_004410.3). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human |
ポジティブサンプル: | Raji |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 315-384 of human DUSP5 (NP_004410.3). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | SEIL PSTP NPQP PSCQ GEAA GSSL IGHL QTLS PDMQ GAYC TFPA SVLA PVPT HSTV SELS RSPV ATAT SC |
遺伝子ID: | 1847 |
Uniprot: | Q16690 |
セルラーロケーション: | Nucleus |
計算された分子量: | 42kDa |
観察された分子量: | 42kDa |
同義語: | DUSP5, DUSP, HVH3 |
バックグラウンド: | The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus. |
UniProt Protein Function: | Function: Displays phosphatase activity toward several substrates. The highest relative activity is toward ERK1. |
UniProt Protein Details: | Catalytic activity: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.A phosphoprotein + H2O = a protein + phosphate. Subcellular location: Nucleus Potential. Sequence similarities: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.Contains 1 rhodanese domain.Contains 1 tyrosine-protein phosphatase domain. |
NCBI Summary: | The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q16690 |
NCBI GenInfo Identifier: | 62865890 |
NCBI Gene ID: | 1847 |
NCBI Accession: | NP_004410 |
UniProt Related Accession: | Q16690 |
Molecular Weight: | 42kDa |
NCBI Full Name: | dual specificity protein phosphatase 5 |
NCBI Synonym Full Names: | dual specificity phosphatase 5 |
NCBI Official Symbol: | DUSP5 |
NCBI Official Synonym Symbols: | DUSP; HVH3 |
NCBI Protein Information: | dual specificity protein phosphatase 5 |
UniProt Protein Name: | Dual specificity protein phosphatase 5 |
UniProt Synonym Protein Names: | Dual specificity protein phosphatase hVH3 |
Protein Family: | Dual specificity protein phosphatase |
UniProt Gene Name: | DUSP5 |
UniProt Entry Name: | DUS5_HUMAN |
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