| バックグラウンド: | The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus. |
| UniProt Code: | Q05923 |
| NCBI GenInfo Identifier: | 4758206 |
| NCBI Gene ID: | 1844 |
| NCBI Accession: | NP_004409 |
| UniProt Secondary Accession: | Q05923,Q53T45, |
| UniProt Related Accession: | Q05923 |
| Molecular Weight: | 34,400 Da |
| NCBI Full Name: | dual specificity protein phosphatase 2 |
| NCBI Synonym Full Names: | dual specificity phosphatase 2 |
| NCBI Official Symbol: | DUSP2 |
| NCBI Official Synonym Symbols: | PAC1; PAC-1 |
| NCBI Protein Information: | dual specificity protein phosphatase 2; dual specificity protein phosphatase PAC-1; dual-specificity phosphatase 2; serine/threonine specific protein phosphatase |
| UniProt Protein Name: | Dual specificity protein phosphatase 2 |
| UniProt Synonym Protein Names: | Dual specificity protein phosphatase PAC-1 |
| Protein Family: | Dual specificity protein phosphatase |
| UniProt Gene Name: | DUSP2 |
| UniProt Entry Name: | DUS2_HUMAN |
