Anti-DUSP19 Antibody (CAB6227)
- SKU:
- CAB6227
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-DUSP19 Antibody |
| 抗体コード: | CAB6227 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-95 of human DUSP19 (NP_543152.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HeLa, Mouse skeletal muscle, Mouse uterus, Rat skeletal muscle, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-95 of human DUSP19 (NP_543152.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MYSL NQEI KAFS RNNL RKQC TRVT TLTG KKII ETWK DARI HVVE EVEP SSGG GCGY VQDL SSDL QVGV IKPW LLLG SQDA AHDL DTLK KNKV THI |
| 遺伝子ID: | 142679 |
| Uniprot: | Q8WTR2 |
| セルラーロケーション: | |
| 計算された分子量: | 18kDa/24kDa |
| 観察された分子量: | 30kDa |
| 同義語: | DUSP19, DUSP17, LMWDSP3, SKRP1, TS-DSP1 |
| バックグラウンド: |
| UniProt Protein Function: | DUSP19: Has a dual specificity toward Ser/Thr and Tyr-containing proteins. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Protein phosphatase, dual-specificity; EC 3.1.3.48; EC 3.1.3.16; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 2q32.1 Cellular Component: cytoplasm Molecular Function:protein tyrosine/threonine phosphatase activity; JUN kinase phosphatase activity; MAP-kinase scaffold activity; protein kinase inhibitor activity; protein tyrosine phosphatase activity; mitogen-activated protein kinase kinase kinase binding; protein kinase activator activity Biological Process: negative regulation of JNK activity; negative regulation of JNK cascade; positive regulation of JNK activity; positive regulation of MAPKKK cascade; positive regulation of protein kinase activity; JNK cascade; positive regulation of JNK cascade; negative regulation of protein kinase activity; protein amino acid dephosphorylation; inactivation of MAPK activity |
| NCBI Summary: | Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009] |
| UniProt Code: | Q8WTR2 |
| NCBI GenInfo Identifier: | 29840769 |
| NCBI Gene ID: | 142679 |
| NCBI Accession: | Q8WTR2.1 |
| UniProt Secondary Accession: | Q8WTR2,Q547H4, Q8WYN4, B2RA79, |
| UniProt Related Accession: | Q8WTR2 |
| Molecular Weight: | 217 |
| NCBI Full Name: | Dual specificity protein phosphatase 19 |
| NCBI Synonym Full Names: | dual specificity phosphatase 19 |
| NCBI Official Symbol: | DUSP19 |
| NCBI Official Synonym Symbols: | SKRP1; DUSP17; LMWDSP3; TS-DSP1 |
| NCBI Protein Information: | dual specificity protein phosphatase 19; LMW-DSP3; protein phosphatase SKRP1; dual specificity phosphatase TS-DSP1; SAPK pathway-regulating phosphatase 1; low molecular weight dual specificity phosphatase 3; stress-activated protein kinase pathway-regulating phosphatase 1 |
| UniProt Protein Name: | Dual specificity protein phosphatase 19 |
| UniProt Synonym Protein Names: | Dual specificity phosphatase TS-DSP1; Low molecular weight dual specificity phosphatase 3; LMW-DSP3; Protein phosphatase SKRP1; Stress-activated protein kinase pathway-regulating phosphatase 1; SAPK pathway-regulating phosphatase 1 |
| Protein Family: | Dual specificity protein phosphatase |
| UniProt Gene Name: | DUSP19 |
| UniProt Entry Name: | DUS19_HUMAN |
 | Western blot analysis of extracts of various cell lines, using DUSP19 antibody (CAB6227) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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