| UniProt Protein Function: | DUSP14: a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (ERK, JNK, p38). Is a negative regulator of T cell costimulation via CD28. |
| UniProt Protein Details: | Protein type:EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity Chromosomal Location of Human Ortholog: 17q12 Molecular Function:protein binding; RNA binding |
| NCBI Summary: | Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009] |
| UniProt Code: | O95147 |
| NCBI GenInfo Identifier: | 20137720 |
| NCBI Gene ID: | 11072 |
| NCBI Accession: | O95147.1 |
| UniProt Related Accession: | O95147 |
| Molecular Weight: | 22kDa |
| NCBI Full Name: | Dual specificity protein phosphatase 14 |
| NCBI Synonym Full Names: | dual specificity phosphatase 14 |
| NCBI Official Symbol: | DUSP14 |
| NCBI Official Synonym Symbols: | MKP6; MKP-L |
| NCBI Protein Information: | dual specificity protein phosphatase 14 |
| UniProt Protein Name: | Dual specificity protein phosphatase 14 |
| UniProt Synonym Protein Names: | MKP-1-like protein tyrosine phosphatase; MKP-L; Mitogen-activated protein kinase phosphatase 6; MAP kinase phosphatase 6; MKP-6 |
| Protein Family: | Dual specificity protein phosphatase |
| UniProt Gene Name: | DUSP14 |
