Anti-DUSP12 Antibody (CAB2725)
- SKU:
- CAB2725
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-DUSP12 Antibody |
| 抗体コード: | CAB2725 |
| 抗体サイズ: | 100µL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human DUSP12 |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:200 - 1:1000 IHC 1:25 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Jurkat |
| 免疫原: | Recombinant protein of human DUSP12 |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 11266 |
| Uniprot: | Q9UNI6 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 37kDa |
| 観察された分子量: | 37kDa |
| 同義語: | DUSP12, DUSP1, YVH1 |
| バックグラウンド: | The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. |
| UniProt Protein Function: | DUSP12: is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. [provided by RefSeq, Jul 2008] |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; EC 3.1.3.16; EC 3.1.3.48; Protein phosphatase, dual-specificity Chromosomal Location of Human Ortholog: 1q21-q22 Cellular Component: cytoplasm; nucleus Molecular Function:zinc ion binding; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; kinase binding Biological Process: protein modification process; protein amino acid dephosphorylation; positive regulation of glucokinase activity |
| NCBI Summary: | The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UNI6 |
| NCBI GenInfo Identifier: | 9973073 |
| NCBI Gene ID: | 11266 |
| NCBI Accession: | Q9UNI6.1 |
| UniProt Secondary Accession: | Q9UNI6,Q9D0T2, |
| UniProt Related Accession: | Q9UNI6 |
| Molecular Weight: | 340 |
| NCBI Full Name: | Dual specificity protein phosphatase 12 |
| NCBI Synonym Full Names: | dual specificity phosphatase 12 |
| NCBI Official Symbol: | DUSP12 |
| NCBI Official Synonym Symbols: | YVH1; DUSP1 |
| NCBI Protein Information: | dual specificity protein phosphatase 12; YVH1 protein-tyrosine phosphatase ortholog; dual specificity tyrosine phosphatase YVH1; serine/threonine specific protein phosphatase |
| UniProt Protein Name: | Dual specificity protein phosphatase 12 |
| UniProt Synonym Protein Names: | Dual specificity tyrosine phosphatase YVH1 |
| Protein Family: | Dual specificity protein phosphatase |
| UniProt Gene Name: | DUSP12 |
| UniProt Entry Name: | DUS12_HUMAN |
 | Western blot analysis of extracts of Jurkat cells, using DUSP12 antibody (CAB2725). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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