Anti-DSTN Antibody (CAB11603)
- SKU:
- CAB11603
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-DSTN Antibody |
| 抗体コード: | CAB11603 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-165 of human DSTN (NP_006861.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | A-549, HeLa |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-165 of human DSTN (NP_006861.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MASG VQVA DEVC RIFY DMKV RKCS TPEE IKKR KKAV IFCL SADK KCII VEEG KEIL VGDV GVTI TDPF KHFV GMLP EKDC RYAL YDAS FETK ESRK EELM FFLW APEL APLK SKMI YASS KDAI KKKF QGIK HECQ ANGP EDLN RACI AEKL GGSL IVAF EGCP V |
| 遺伝子ID: | 11034 |
| Uniprot: | P60981 |
| セルラーロケーション: | |
| 計算された分子量: | 16kDa/18kDa |
| 観察された分子量: | 15kDa |
| 同義語: | DSTN, ACTDP, ADF, HEL32, bA462D18.2, destrin |
| バックグラウンド: | The product of this gene belongs to the actin-binding proteins ADF family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene. |
| UniProt Protein Function: | Destrin: an actin-depolymerizing cytoskeletal protein that belongs to the ADF actin-binding protein family. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Present in many vertebrate tissues and particularly abundant in neuronal cells. It binds F-actin in a pH-dependent manner which affects it's severing/depolymerizing activities. It also binds G-actin at pH 8.0 thereby sequestering monomers and preventing polymerization. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Actin-binding Chromosomal Location of Human Ortholog: 20p12.1 Cellular Component: actin cytoskeleton Molecular Function:protein binding Biological Process: actin polymerization and/or depolymerization |
| NCBI Summary: | The product of this gene belongs to the actin-binding proteins ADF family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P60981 |
| NCBI GenInfo Identifier: | 46577586 |
| NCBI Gene ID: | 11034 |
| NCBI Accession: | P60981.3 |
| UniProt Secondary Accession: | P60981,P18282, Q5W166, Q6IAW2, B2R6N2, B4DYA6, |
| UniProt Related Accession: | P60981 |
| Molecular Weight: | 16,621 Da |
| NCBI Full Name: | Destrin |
| NCBI Synonym Full Names: | destrin, actin depolymerizing factor |
| NCBI Official Symbol: | DSTN |
| NCBI Official Synonym Symbols: | ADF; ACTDP; HEL32; bA462D18.2 |
| NCBI Protein Information: | destrin |
| UniProt Protein Name: | Destrin |
| UniProt Synonym Protein Names: | Actin-depolymerizing factor; ADF |
| Protein Family: | Destrin |
| UniProt Gene Name: | DSTN |
| UniProt Entry Name: | DEST_HUMAN |
 | Western blot analysis of extracts of various cell lines, using DSTN antibody (CAB11603) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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