Anti-DST Antibody (CAB2013)
- SKU:
- CAB2013
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-DST Antibody |
| 抗体コード: | CAB2013 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human DST (NP_001714.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | THP-1, Rat kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human DST (NP_001714.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MHSS SYSY RSSD SVFS NTTS TRTS LDSN ENLL LVHC GPTL INSC ISFG SESF DGHR LEML QQIA NRVQ RDSV ICED KLIL AGNA LQSD SKRL ESGV QFQN EAEI AGYI LECE NLLR QHVI DVQI LIDG KYYQ ADQL VQRV AKLR DEIM ALRN ECSS VYSK GRIL TTEQ TKLM ISGI TQSL NSGF AQTL HPSL TSGL TQSL TPSL TSSS MTSG LSSG MTSR LTPS VTPA YTPG FPSG LVPN FSSG VEPN SLQT LKLM QIRK PLLK SSLL DQ |
| 遺伝子ID: | 667 |
| Uniprot: | Q03001 |
| セルラーロケーション: | Cell junction, Cell membrane, Cell projection, Cytoplasm, Endoplasmic reticulum membrane, H zone, Lipid-anchor, Membrane, Nucleus, Nucleus envelope, Single-pass membrane protein, Z line, axon, cell cortex, cytoskeleton, cytoskeleton, hemidesmosome, myofibril, sarcomere |
| 計算された分子量: | 9kDa/25kDa/50kDa/102kDa/306-860kDa |
| 観察された分子量: | 105kDa |
| 同義語: | DST, BP240, BPA, BPAG1, CATX-15, CATX15, D6S1101, DMH, DT, EBSB2, HSAN6, MACF2, dystonin |
| バックグラウンド: | This gene encodes a member of the plakin protein family of adhesion junction plaque proteins. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of some variants has not been defined. It has been reported that some isoforms are expressed in neural and muscle tissue, anchoring neural intermediate filaments to the actin cytoskeleton, and some isoforms are expressed in epithelial tissue, anchoring keratin-containing intermediate filaments to hemidesmosomes. Consistent with the expression, mice defective for this gene show skin blistering and neurodegeneration. |
| UniProt Protein Function: | BPAG1 iso3: a protein of the plakin family. Plakins are multi-domain proteins that have been shown to interact with microtubules, actin filaments and intermediate filaments, as well as proteins found in cellular junctions. Ten alternatively spliced human isoforms have been reported. BPAG1 has neuronal and muscle isoforms that consist of actin-binding and microtubule-binding domains at either end separated by a plakin domain and many spectrin repeats. Bpag1 isoforms with different N-termini may have differing roles. The plakin domain contains an apparent nuclear localization signal. |
| UniProt Protein Details: | Protein type:Microtubule-binding; Cytoskeletal; Motility/polarity/chemotaxis; Actin-binding Chromosomal Location of Human Ortholog: 6p12.1 Cellular Component: endoplasmic reticulum membrane; intermediate filament cytoskeleton; focal adhesion; cytoplasmic membrane-bound vesicle; leading edge; integral to membrane; intermediate filament; nuclear envelope; cell cortex; Z disc; cytosol; actin cytoskeleton; microtubule cytoskeleton; hemidesmosome; axon; cytoplasm; basal plasma membrane; basement membrane; nucleus Molecular Function:protein C-terminus binding; integrin binding; microtubule plus-end binding; protein binding; protein homodimerization activity; calcium ion binding; actin binding Biological Process: integrin-mediated signaling pathway; hemidesmosome assembly; extracellular matrix organization and biogenesis; cell motility involved in cell locomotion; response to wounding; intermediate filament cytoskeleton organization and biogenesis; cytoskeleton organization and biogenesis; microtubule cytoskeleton organization and biogenesis; cell cycle arrest; cell adhesion; maintenance of cell polarity |
| NCBI Summary: | This gene encodes a member of the plakin protein family of adhesion junction plaque proteins. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of some variants has not been defined. It has been reported that some isoforms are expressed in neural and muscle tissue, anchoring neural intermediate filaments to the actin cytoskeleton, and some isoforms are expressed in epithelial tissue, anchoring keratin-containing intermediate filaments to hemidesmosomes. Consistent with the expression, mice defective for this gene show skin blistering and neurodegeneration. [provided by RefSeq, Mar 2010] |
| UniProt Code: | Q03001 |
| NCBI GenInfo Identifier: | 294862529 |
| NCBI Gene ID: | 667 |
| NCBI Accession: | Q03001.4 |
| UniProt Secondary Accession: | Q03001,O94833, Q12825, Q13266, Q13267, Q13775, Q5TBT0 Q5TBT2, Q5TF23, Q5TF24, Q8N1T8, B7Z3H1, |
| UniProt Related Accession: | Q03001 |
| Molecular Weight: | 7570 |
| NCBI Full Name: | Dystonin |
| NCBI Synonym Full Names: | dystonin |
| NCBI Official Symbol: | DST |
| NCBI Official Synonym Symbols: | DT; BPA; DMH; BP240; BPAG1; EBSB2; HSAN6; MACF2; CATX15; CATX-15; D6S1101 |
| NCBI Protein Information: | dystonin; trabeculin-beta; dystonia musculorum protein; bullous pemphigoid antigen 1; hemidesmosomal plaque protein |
| UniProt Protein Name: | Dystonin |
| UniProt Synonym Protein Names: | 230 kDa bullous pemphigoid antigen; 230/240 kDa bullous pemphigoid antigen; Bullous pemphigoid antigen 1; BPA; Bullous pemphigoid antigen; Dystonia musculorum protein; Hemidesmosomal plaque protein |
| Protein Family: | Dystonin |
| UniProt Gene Name: | DST |
| UniProt Entry Name: | DYST_HUMAN |
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