Anti-DSG2 Antibody (CAB19996)[KO Validated]
![Anti-DSG2 Antibody (CAB19996)[KO Validated]](https://cdn11.bigcommerce.com/s-d5atsu6k01/images/stencil/608x608/products/24014/23862/anti-dsg2-antibody-cab19996ko-validated__26136__34554.1645805805.jpg?c=1 "Anti-DSG2 Antibody (CAB19996)[KO Validated]")
- SKU:
- CAB19996
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
![Anti-DSG2 Antibody (CAB19996)[KO Validated]](https://cdn11.bigcommerce.com/s-d5atsu6k01/images/stencil/1280x1280/products/24014/23862/anti-dsg2-antibody-cab19996ko-validated__26136__34554.1645805805.jpg?c=1&imbypass=on "Anti-DSG2 Antibody (CAB19996)[KO Validated]")
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Description
| 抗体名: | Anti-DSG2 Antibody [KO Validated] |
| 抗体コード: | CAB19996 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human DSG2. |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | A-549 |
| 免疫原: | Recombinant protein of human DSG2. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 1829 |
| Uniprot: | Q14126 |
| セルラーロケーション: | Cell junction, Cell membrane, Single-pass type I membrane protein, desmosome |
| 計算された分子量: | 122kDa |
| 観察された分子量: | 150KDa |
![Anti-DSG2 Antibody [KO Validated] (CAB19996)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/product_images/m/083/A19996_1__75106.jpg) | Western blot analysis of extracts from normal (control) and DSG2 knockout (KO) A-549 cells, using DSG2 antibody (CAB19996) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
| 同義語: | DSG2, CDHF5, HDGC |
| バックグラウンド: | This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10. |
| UniProt Protein Function: | DSG2: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Defects in DSG2 are the cause of familial arrhythmogenic right ventricular dysplasia type 10 (ARVD10); also known as arrhythmogenic right ventricular cardiomyopathy 10 (ARVC10). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall. Genetic variations in DSG2 are the cause of susceptibility to cardiomyopathy dilated type 1BB (CMD1BB). A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cell adhesion; Calcium-binding Chromosomal Location of Human Ortholog: 18q12.1 Cellular Component: desmosome; cell surface; apical plasma membrane; integral to membrane; plasma membrane; intercellular junction; lateral plasma membrane Molecular Function:calcium ion binding Biological Process: maternal process involved in pregnancy; apoptosis; homophilic cell adhesion; response to progesterone stimulus; cell adhesion; cell structure disassembly during apoptosis Disease: Cardiomyopathy, Dilated, 1bb; Arrhythmogenic Right Ventricular Dysplasia, Familial, 10 |
| NCBI Summary: | Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. This gene product is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q14126 |
| NCBI GenInfo Identifier: | 148876773 |
| NCBI Gene ID: | 1829 |
| NCBI Accession: | Q14126.2 |
| UniProt Secondary Accession: | Q14126,Q4KKU6, |
| UniProt Related Accession: | Q14126 |
| Molecular Weight: | |
| NCBI Full Name: | Desmoglein-2 |
| NCBI Synonym Full Names: | desmoglein 2 |
| NCBI Official Symbol: | DSG2 |
| NCBI Official Synonym Symbols: | HDGC; CDHF5; ARVC10; ARVD10; CMD1BB |
| NCBI Protein Information: | desmoglein-2; HDGC; cadherin family member 5 |
| UniProt Protein Name: | Desmoglein-2 |
| UniProt Synonym Protein Names: | Cadherin family member 5; HDGC |
| Protein Family: | Desmoglein |
| UniProt Gene Name: | DSG2 |
| UniProt Entry Name: | DSG2_HUMAN |