Anti-Drosha Antibody (CAB19598)
- SKU:
- CAB19598
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-Drosha Antibody |
抗体コード: | CAB19598 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | A synthesized peptide derived from human Drosha. |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
反応性: | Human |
ポジティブサンプル: | 293T, HeLa, Jurkat, HepG2 |
免疫原: | A synthesized peptide derived from human Drosha. |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 29102 |
Uniprot: | Q9NRR4 |
セルラーロケーション: | |
計算された分子量: | 159kDa |
観察された分子量: | 159KDa |
同義語: | DROSHA, ETOHI2, HSA242976, RANSE3L, RN3, RNASE3L, RNASEN |
バックグラウンド: | This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer. [provided by RefSeq, Sep 2016] |
UniProt Protein Function: | Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. |
NCBI Summary: | This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer. [provided by RefSeq, Sep 2016] |
UniProt Code: | Q9NRR4 |
NCBI GenInfo Identifier: | 155030236 |
NCBI Gene ID: | 29102 |
NCBI Accession: | NP_001093882.1 |
UniProt Related Accession: | Q9NRR4 |
Molecular Weight: | |
NCBI Full Name: | ribonuclease 3 isoform 2 |
NCBI Synonym Full Names: | drosha ribonuclease III |
NCBI Official Symbol: | DROSHA |
NCBI Official Synonym Symbols: | RN3; ETOHI2; RNASEN; RANSE3L; RNASE3L; HSA242976 |
NCBI Protein Information: | ribonuclease 3 |
UniProt Protein Name: | Ribonuclease 3 |
UniProt Synonym Protein Names: | Protein Drosha |
UniProt Gene Name: | DROSHA |