Anti-DRAP1 Antibody (CAB17616)
- SKU:
- CAB17616
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
抗体名: | Anti-DRAP1 Antibody |
抗体コード: | CAB17616 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-150 of human DRAP1 (NP_006433.2). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | U-87MG, Jurkat, 293T, Rat testis |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-150 of human DRAP1 (NP_006433.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | LKKA CQVT QSRN AKTM TTSH LKQC IELE QQFD FLKD LVAS VPDM QGDG EDNH MDGD KGAR RGRK PGSG GRKN GGMG TKSK DKKL SGTD SEQE DESE DTDT D |
遺伝子ID: | 10589 |
Uniprot: | Q14919 |
セルラーロケーション: | |
計算された分子量: | |
観察された分子量: | 32-38kDa |
同義語: | NC2-alpha, DRAP1 |
バックグラウンド: | Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex. [provided by RefSeq, Jul 2008] |
UniProt Protein Function: | The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. |
NCBI Summary: | Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q14919 |
NCBI GenInfo Identifier: | 56404465 |
NCBI Gene ID: | 10589 |
NCBI Accession: | Q14919.3 |
UniProt Secondary Accession: | Q14919,Q13448, |
UniProt Related Accession: | Q14919 |
Molecular Weight: | 23,148 Da |
NCBI Full Name: | Dr1-associated corepressor |
NCBI Synonym Full Names: | DR1 associated protein 1 |
NCBI Official Symbol: | DRAP1 |
NCBI Official Synonym Symbols: | NC2-alpha |
NCBI Protein Information: | dr1-associated corepressor |
UniProt Protein Name: | Dr1-associated corepressor |
UniProt Synonym Protein Names: | Dr1-associated protein 1; Negative cofactor 2-alpha; NC2-alpha |
Protein Family: | Dr1-associated corepressor |
UniProt Gene Name: | DRAP1 |
UniProt Entry Name: | NC2A_HUMAN |