Anti-DPYS Antibody (CAB6368)
- SKU:
- CAB6368
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-DPYS Antibody |
| 抗体コード: | CAB6368 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 250-519 of human DPYS (NP_001376.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: | Mouse liver, Mouse kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 250-519 of human DPYS (NP_001376.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MSKS AAKV IADA RRDG KVVY GEPI AASL GTDG THYW NKEW HHAA HHVM GPPL RPDP STPD FLMN LLAN DDLT TTGT DNCT FNTC QKAL GKDD FTKI PNGV NGVE DRMS VIWE KGVH SGKM DENR FVAV TSTN AAKI FNLY PRKG RIAV GSDA DIVI WDPK GTRT ISAK THHQ AVNF NIFE GMVC HGVP LVTI SRGK VVYE AGVF SVTA GDGK FIPR KPFA EYIY KRIK QRDR TCTP TPVE RAPY KGEV ATLK SRVT KEDA TAGT RKQA HP |
| 遺伝子ID: | 1807 |
| Uniprot: | Q14117 |
| セルラーロケーション: | |
| 計算された分子量: | 56kDa |
| 観察された分子量: | 54kDa |
| 同義語: | DPYS, DHP, DHPase |
| バックグラウンド: | Dihydropyrimidinase catalyzes the conversion of 5, 6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria. |
| UniProt Protein Function: | DPYS: Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6- dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate. Defects in DPYS are the cause of dihydropyrimidinase deficiency (DHPD). DHPD is an autosomal recessive disorder characterized by dihydropyrimidinuria and associated with a variable clinical phenotype: epileptic or convulsive attacks, dysmorphic features and severe developmental delay, and congenital microvillous atrophy. Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily. |
| UniProt Protein Details: | Protein type:Xenobiotic Metabolism - drug metabolism - other enzymes; Hydrolase; EC 3.5.2.2; Other Amino Acids Metabolism - beta-alanine; Nucleotide Metabolism - pyrimidine; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis Chromosomal Location of Human Ortholog: 8q22 Cellular Component: cytosol Molecular Function:dihydropyrimidinase activity Biological Process: protein homotetramerization; pyrimidine base catabolic process; pyrimidine nucleoside catabolic process; thymine catabolic process; uracil catabolic process Disease: Dihydropyrimidinase Deficiency |
| NCBI Summary: | Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q14117 |
| NCBI GenInfo Identifier: | 3122049 |
| NCBI Gene ID: | 1807 |
| NCBI Accession: | Q14117.1 |
| UniProt Related Accession: | Q14117 |
| Molecular Weight: | 56,630 Da |
| NCBI Full Name: | Dihydropyrimidinase |
| NCBI Synonym Full Names: | dihydropyrimidinase |
| NCBI Official Symbol: | DPYS |
| NCBI Official Synonym Symbols: | DHP; DHPase |
| NCBI Protein Information: | dihydropyrimidinase |
| UniProt Protein Name: | Dihydropyrimidinase |
| UniProt Synonym Protein Names: | Dihydropyrimidine amidohydrolase; Hydantoinase |
| UniProt Gene Name: | DPYS |
| UniProt Entry Name: | DPYS_HUMAN |
 | Western blot analysis of extracts of various cell lines, using DPYS antibody (CAB6368) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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