Anti-DPP6 Antibody (CAB10210)
- SKU:
- CAB10210
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-DPP6 Antibody |
| 抗体コード: | CAB10210 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 117-210 of human DPP6 (NP_001277182.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:1000 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | 293T |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 117-210 of human DPP6 (NP_001277182.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LTPA EDNS LSQK KKVT VEDL FSED FKIH DPEA KWIS DTEF IYRE QKGT VRLW NVET NTST VLIE GKKI ESLR AIRY EISP DREY ALFS YNVE PM |
| 遺伝子ID: | 1804 |
| Uniprot: | P42658 |
| セルラーロケーション: | Cell membrane, Single-pass type II membrane protein |
| 計算された分子量: | 91kDa/97kDa |
| 観察された分子量: | 105kDa |
| 同義語: | DPP6, DPL1, DPPX, MRD33, VF2 |
| バックグラウンド: | This gene encodes a single-pass type II membrane protein that is a member of the peptidase S9B family of serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Variations in this gene may be associated with susceptibility to amyotrophic lateral sclerosis and with idiopathic ventricular fibrillation. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | DPP6: May be involved in the physiological processes of brain function. Has no dipeptidyl aminopeptidase activity. May modulate the cell surface expression and the activity of the potassium channel KCND2. Defects in DPP6 are the cause of familial paroxysmal ventricular fibrillation type 2 (VF2). A cardiac arrhythmia marked by fibrillary contractions of the ventricular muscle due to rapid repetitive excitation of myocardial fibers without coordinated contraction of the ventricle and by absence of atrial activity. A genetic variation 340 bases upstream from the ATG start site of the DPP6 gene is the cause of familial paroxysmal ventricular fibrillation type 2. Belongs to the peptidase S9B family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Protease; Membrane protein, integral Chromosomal Location of Human Ortholog: 7q36.2 Cellular Component: voltage-gated potassium channel complex; integral to membrane; plasma membrane Molecular Function:potassium channel regulator activity; serine-type peptidase activity; dipeptidyl-peptidase activity Biological Process: generation of action potential; proteolysis Disease: Ventricular Fibrillation, Paroxysmal Familial, 2; Mental Retardation, Autosomal Dominant 33 |
| NCBI Summary: | This gene encodes a single-pass type II membrane protein that is a member of the peptidase S9B family of serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Variations in this gene may be associated with susceptibility to amyotrophic lateral sclerosis and with idiopathic ventricular fibrillation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014] |
| UniProt Code: | P42658 |
| NCBI GenInfo Identifier: | 218512016 |
| NCBI Gene ID: | 1804 |
| NCBI Accession: | P42658.2 |
| UniProt Related Accession: | P42658 |
| Molecular Weight: | Observed Molecular Weight: (Observed)97kD.Predicted Molecular Weight: (Calculated)98kDa. |
| NCBI Full Name: | Dipeptidyl aminopeptidase-like protein 6 |
| NCBI Synonym Full Names: | dipeptidyl peptidase like 6 |
| NCBI Official Symbol: | DPP6 |
| NCBI Official Synonym Symbols: | VF2; DPL1; DPPX; MRD33 |
| NCBI Protein Information: | dipeptidyl aminopeptidase-like protein 6 |
| UniProt Protein Name: | Dipeptidyl aminopeptidase-like protein 6 |
| UniProt Synonym Protein Names: | DPPX; Dipeptidyl aminopeptidase-related protein; Dipeptidyl peptidase 6; Dipeptidyl peptidase IV-like protein; Dipeptidyl peptidase VI |
| Protein Family: | Dipeptidyl aminopeptidase-like protein |
| UniProt Gene Name: | DPP6 |
| UniProt Entry Name: | DPP6_HUMAN |
 | Western blot analysis of extracts of 293T cells, using DPP6 antibody (CAB10210) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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