Anti-Docking protein 2 Antibody (CAB8472)
- SKU:
- CAB8472
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Frequently bought together:
Description
| 抗体名: | Anti-Docking protein 2 Antibody |
| 抗体コード: | CAB8472 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human DOK2 (NP_003965.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | U-251MG |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human DOK2 (NP_003965.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MGDG AVKQ GFLY LQQQ QTFG KKWR RFGA SLYG GSDC ALAR LELQ EGPE KPRR CEAA RKVI RLSD CLRV AEAG GEAS SPRD TSAF FLET KERL YLLA APAA ERGD WVQA ICLL AFPG QRKE LSGP EGKQ SRPC MEEN ELYS SAVT VGPH KEFA VTMR PTEA SERC HLRG SYTL RAGE SALE LWGG PEPG TQLY DWPY RFLR RFGR DKVT FSFE AGRR CVSG EGNF EFET RQGN EIFL ALEE AISA QKNA APAT PQPQ PATI |
| 遺伝子ID: | 9046 |
| Uniprot: | O60496 |
| セルラーロケーション: | |
| 計算された分子量: | 45kDa |
| 観察された分子量: | 45kDa |
| 同義語: | DOK2, p56DOK, p56dok-2 |
| バックグラウンド: | The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells. |
| UniProt Protein Function: | DOK2: a member of the p62dok family of proteins that interact with receptor tyrosine kinases and mediate particular biological responses. Constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/Abl), a chimeric protein whose presence is associated with CML. Contains a pleckstrin homology domain at the amino terminus, 13 potential tyrosine phosphorylation sites, and six PXXP SH3 recognition motifs. Binds p120 (RasGAP) from CML cells. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 8p21.3 Cellular Component: cytosol Molecular Function:insulin receptor binding; protein binding; receptor signaling protein activity; transmembrane receptor protein tyrosine kinase adaptor protein activity Biological Process: blood coagulation; cell surface receptor linked signal transduction; leukocyte migration; Ras protein signal transduction; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway |
| NCBI Summary: | The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O60496 |
| NCBI GenInfo Identifier: | 143220234 |
| NCBI Gene ID: | 9046 |
| NCBI Accession: | O60496.2 |
| UniProt Secondary Accession: | O60496,Q8N5A4, |
| UniProt Related Accession: | O60496 |
| Molecular Weight: | 45,379 Da |
| NCBI Full Name: | Docking protein 2 |
| NCBI Synonym Full Names: | docking protein 2 |
| NCBI Official Symbol: | DOK2 |
| NCBI Official Synonym Symbols: | p56DOK; p56dok-2 |
| NCBI Protein Information: | docking protein 2 |
| UniProt Protein Name: | Docking protein 2 |
| UniProt Synonym Protein Names: | Downstream of tyrosine kinase 2; p56(dok-2) |
| Protein Family: | Docking protein |
| UniProt Gene Name: | DOK2 |
| UniProt Entry Name: | DOK2_HUMAN |
 | Western blot analysis of extracts of U-251MG cells, using DOK2 antibody (CAB8472) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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