Anti-DOCK8 Antibody (CAB7998)
- SKU:
- CAB7998
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | DOCK8 Rabbit Polyclonal Antibody |
| 抗体コード: | CAB7998 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1900-2099 of human DOCK8 (NP_982272.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1900-2099 of human DOCK8 (NP_982272.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | TLEG RPRG ELHE QYRR NTVL TTMH AFPY IKTR ISVI QKEE FVLT PIEV AIED MKKK TLQL AVAI NQEP PDAK MLQM VLQG SVGA TVNQ GPLE VAQV FLAE IPAD PKLY RHHN KLRL CFKE FIMR CGEA VEKN KRLI TADQ REYQ QELK KNYN KLKE NLRP MIER KIPE LYKP IFRV ESQK RDSF HRSS FRKC ETQL SQGS |
| 遺伝子ID: | 81704 |
| Uniprot: | Q8NF50 |
| セルラーロケーション: | |
| 計算された分子量: | 227kDa/230kDa/235kDa/238kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | DOCK8, HEL-205, MRD2, ZIR8 |
| バックグラウンド: | This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. |
| UniProt Protein Function: | DOCK8: Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Defects in DOCK8 are the cause of hyperimmunoglobulin E recurrent infection syndrome autosomal recessive (AR-HIES). It is a rare disorder of immunity characterized by immunodeficiency, recurrent infections, eczema, increased serum IgE, eosinophilia and lack of connective tissue and skeletal involvement. Defects in DOCK8 are the cause of mental retardation autosomal dominant type 2 (MRD2). Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. A chromosomal aberration disrupting DOCK8 has been found in a patient with mental retardation and ectodermal dysplasia. DOCK8 is disrupted in patients with mental retardation. A balanced translocation, t(X;9) (q13.1;p24). Belongs to the DOCK family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:GEFs; GEFs, misc.; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 9p24.3 Cellular Component: cytosol; membrane Molecular Function:protein binding Biological Process: blood coagulation Disease: Hyper-ige Recurrent Infection Syndrome, Autosomal Recessive; Mental Retardation, Autosomal Dominant 2 |
| NCBI Summary: | This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jun 2010] |
| UniProt Code: | Q8NF50 |
| NCBI GenInfo Identifier: | 158937439 |
| NCBI Gene ID: | 81704 |
| NCBI Accession: | Q8NF50.3 |
| UniProt Secondary Accession: | Q8NF50,Q3MV16, Q5JPJ1, Q8TEP1, Q8WUY2, Q9BYJ5, Q9H1Q2 A2A350, A2BDF2, A4FU78, B7ZLP0, E9PH09, |
| UniProt Related Accession: | Q8NF50 |
| Molecular Weight: | 227,477 Da |
| NCBI Full Name: | Dedicator of cytokinesis protein 8 |
| NCBI Synonym Full Names: | dedicator of cytokinesis 8 |
| NCBI Official Symbol: | DOCK8 |
| NCBI Official Synonym Symbols: | MRD2; ZIR8; HEL-205 |
| NCBI Protein Information: | dedicator of cytokinesis protein 8 |
| UniProt Protein Name: | Dedicator of cytokinesis protein 8 |
| Protein Family: | Dedicator of cytokinesis protein |
| UniProt Gene Name: | DOCK8 |
| UniProt Entry Name: | DOCK8_HUMAN |
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