| バックグラウンド: | This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized. |
| UniProt Protein Function: | Involved in regulation of adherens junction between cells. Plays a role in cell migration. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP. |
| NCBI Summary: | This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8N1I0 |
| NCBI GenInfo Identifier: | 92091572 |
| NCBI Gene ID: | 9732 |
| NCBI Accession: | NP_055520 |
| UniProt Related Accession: | Q8N1I0 |
| Molecular Weight: | |
| NCBI Full Name: | dedicator of cytokinesis protein 4 isoform 1 |
| NCBI Synonym Full Names: | dedicator of cytokinesis 4 |
| NCBI Official Symbol: | DOCK4 |
| NCBI Protein Information: | dedicator of cytokinesis protein 4 |
| UniProt Protein Name: | Dedicator of cytokinesis protein 4 |
| Protein Family: | Dedicator of cytokinesis protein |
| UniProt Gene Name: | DOCK4 |
