Anti-DOCK4 Antibody (CAB15764)
- SKU:
- CAB15764
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
抗体名: | Anti-DOCK4 Antibody |
抗体コード: | CAB15764 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 150-450 of human DOCK4 (NP_055520.3). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human |
ポジティブサンプル: | DU145 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 150-450 of human DOCK4 (NP_055520.3). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | LDWG NEQL GLDL VPRK EYAM VDPE DISI TELY RLME HRHR KKDT PVQA SSHH LFVQ MKSL MCSN LGEE LEVI FSLF DSKE NRPI SERF FLRL NRNG LPKA PDKP ERHC SLFV DLGS SELR KDIY ITVH IIRI GRMG AGEK KNAC SVQY RRPF GCAV LSIA DLLT GETK DDLI LKVY MCNT ESEW YQIH ENII KKLN ARYN LTGS NAGL AVSL QLLH GDIE QIRR EYSS VFSH GVSI TRKL GFSN IIMP GEMR NDLY ITIE RGEF EKGG KSVA RNVE VTMF IVDS SGQT LKDF ISFG SGEP P |
遺伝子ID: | 9732 |
Uniprot: | Q8N1I0 |
セルラーロケーション: | Cytoplasm, Endomembrane system, Peripheral membrane protein, cytosol |
計算された分子量: | 29kDa/222kDa/225kDa/226kDa |
観察された分子量: | 235kDa |
同義語: | DOCK4 |
バックグラウンド: | This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized. |
UniProt Protein Function: | Involved in regulation of adherens junction between cells. Plays a role in cell migration. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP. |
NCBI Summary: | This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q8N1I0 |
NCBI GenInfo Identifier: | 92091572 |
NCBI Gene ID: | 9732 |
NCBI Accession: | NP_055520 |
UniProt Related Accession: | Q8N1I0 |
Molecular Weight: | |
NCBI Full Name: | dedicator of cytokinesis protein 4 isoform 1 |
NCBI Synonym Full Names: | dedicator of cytokinesis 4 |
NCBI Official Symbol: | DOCK4 |
NCBI Protein Information: | dedicator of cytokinesis protein 4 |
UniProt Protein Name: | Dedicator of cytokinesis protein 4 |
Protein Family: | Dedicator of cytokinesis protein |
UniProt Gene Name: | DOCK4 |
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