Anti-DNASE1 Antibody (CAB14531)
- SKU:
- CAB14531
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
| 抗体名: | Anti-DNASE1 Antibody |
| 抗体コード: | CAB14531 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-235 of human DNASE1 (NP_005214.2). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-235 of human DNASE1 (NP_005214.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | IQTF GETK MSNA TLVS YIVQ ILSR YDIA LVQE VRDS HLTA VGKL LDNL NQDA PDTY HYVV SEPL GRNS YKER YLFV YRPD QVSA VDSY YYDD GCEP CGND TFNR EPAI VRFF SRFT EVRE FAIV PLHA APGD AVAE IDAL YDVY LDVQ EKWG LEDV MLMG DFNA GCSY VRPS QWSS IRLW TSPT FQWL IPDS ADTT ATPT HCAY DR |
| 遺伝子ID: | 1773 |
| Uniprot: | P24855 |
| セルラーロケーション: | Nucleus envelope, Secreted |
| 計算された分子量: | 19kDa/31kDa |
| 観察された分子量: | Refer to Figures |
| 同義語: | DNASE1, DNL1, DRNI |
| バックグラウンド: | This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. |
| UniProt Protein Function: | DNASE1: Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization. Defects in DNASE1 are a cause of susceptibility to systemic lupus erythematosus (SLE). A chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Belongs to the DNase I family. |
| UniProt Protein Details: | Protein type:Deoxyribonuclease; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide; EC 3.1.21.1 Chromosomal Location of Human Ortholog: 16p13.3 Cellular Component: extracellular region; nuclear envelope; nucleus Molecular Function:protein binding; deoxyribonuclease I activity; actin binding; endodeoxyribonuclease activity Biological Process: apoptosis; DNA catabolic process, endonucleolytic Disease: Systemic Lupus Erythematosus |
| NCBI Summary: | This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P24855 |
| NCBI GenInfo Identifier: | 118919 |
| NCBI Gene ID: | 1773 |
| NCBI Accession: | P24855.1 |
| UniProt Secondary Accession: | P24855,Q14UU9, Q14UV0, B4DV35, |
| UniProt Related Accession: | P24855 |
| Molecular Weight: | Calculated: 19kDa/31kDaObserved: 37kDa |
| NCBI Full Name: | Deoxyribonuclease-1 |
| NCBI Synonym Full Names: | deoxyribonuclease I |
| NCBI Official Symbol: | DNASE1 |
| NCBI Official Synonym Symbols: | DNL1; DRNI |
| NCBI Protein Information: | deoxyribonuclease-1; Dornase alfa; DNase I, lysosomal; human urine deoxyribonuclease I |
| UniProt Protein Name: | Deoxyribonuclease-1 |
| UniProt Synonym Protein Names: | Deoxyribonuclease I; DNase I; INN: Dornase alfa |
| Protein Family: | Deoxyribonuclease |
| UniProt Gene Name: | DNASE1 |
| UniProt Entry Name: | DNAS1_HUMAN |
 | Immunofluorescence analysis of C6 cells using DNASE1 Polyclonal Antibody (CAB14531) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of NIH-3T3 cells using DNASE1 Polyclonal Antibody (CAB14531) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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