Anti-DNAL1 Antibody (CAB12601)
- SKU:
- CAB12601
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-DNAL1 Antibody |
| 抗体コード: | CAB12601 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 41-190 of human DNAL1 (NP_113615.2). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Raji, HeLa, HepG2, U-251MG, Mouse brain, Rat brain, Rat testis |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 41-190 of human DNAL1 (NP_113615.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | DASL SMLA NCEK LSLS TNCI EKIA NLNG LKNL RILS LGRN NIKN LNGL EAVG DTLE ELWI SYNF IEKL KGIH IMKK LKIL YMSN NLVK DWAE FVKL AELP CLED LVFV GNPL EEKH SAEN NWIE EATK RVPK LKKL DGTP VIKG DEEE DN |
| 遺伝子ID: | 83544 |
| Uniprot: | Q4LDG9 |
| セルラーロケーション: | |
| 計算された分子量: | 8kDa/17kDa/21kDa |
| 観察された分子量: | 22kDa |
| 同義語: | DNAL1, C14orf168, CILD16 |
| バックグラウンド: | This gene encodes an axonemal dynein light chain which functions as a component of the outer dynein arms complex. This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. The encoded protein is expressed in tissues with motile cilia or flagella and may be involved in the movement of sperm flagella. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | DNAL1: Defects in DNAL1 are the cause of primary ciliary dyskinesia type 16 (CILD16). A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. Belongs to the dynein light chain LC1-type family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 14q24.3 Disease: Ciliary Dyskinesia, Primary, 16 |
| NCBI Summary: | This gene encodes an axonemal dynein light chain which functions as a component of the outer dynein arms complex. This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. The encoded protein is expressed in tissues with motile cilia or flagella and may be involved in the movement of sperm flagella. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jan 2011] |
| UniProt Code: | Q4LDG9 |
| NCBI GenInfo Identifier: | 121944344 |
| NCBI Gene ID: | 83544 |
| NCBI Accession: | Q4LDG9.1 |
| UniProt Secondary Accession: | Q4LDG9,Q5JPB7, Q9BS43, B2RD38, |
| UniProt Related Accession: | Q4LDG9 |
| Molecular Weight: | 22kDa |
| NCBI Full Name: | Dynein light chain 1, axonemal |
| NCBI Synonym Full Names: | dynein axonemal light chain 1 |
| NCBI Official Symbol: | DNAL1 |
| NCBI Official Synonym Symbols: | CILD16; C14orf168 |
| NCBI Protein Information: | dynein light chain 1, axonemal |
| UniProt Protein Name: | Dynein light chain 1, axonemal |
| Protein Family: | Dynein |
| UniProt Gene Name: | DNAL1 |
 | Western blot analysis of extracts of various cell lines, using DNAL1 Antibody (CAB12601) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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