Anti-DNA-RNA Hybrid Mouse Monoclonal Antibody (CAB19402)
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- SKU:
- CAB19402
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Reactivity:
- Other (Wide Range)
- Host Species:
- Mouse
- Isotype:
- IgG
Frequently bought together:
Description
| 抗体名: | Anti-DNA-RNA Hybrid Mouse Monoclonal Antibody |
| 抗体コード: | CAB19402 |
| 抗体サイズ: | 20uL, 50 uL |
| 申し込み: | IF IP |
| 反応性: | Human, Mouse, Rat, Other (Wide Range) |
| 宿主種: | Mouse |
| 免疫原: |
| 申し込み: | IF IP |
| 推奨希釈: | IF 1:50 - 1:500 IP 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat, Other (Wide Range) |
| ポジティブサンプル: |
| 免疫原: | |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: ddH?O with 50% glycerol. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | |
| Uniprot: | |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: |
 | Immunofluorescence - DNA-RNA Hybrid Mouse mAb (CAB19402) |
| 同義語: | |
| バックグラウンド: | The R-loop is a special chromosome structure that contains one strand of single-stranded DNA and another strand comprising a DNA:RNA hybrid. The distinct intermediate A/B conformation of the DNA:RNA hybrid makes it more stable than either dsDNA (double-stranded DNA, B form) or dsRNA (A form). R-loops normally form during transcription and play essential roles in key processes including chromatin modification, transcriptional regulation and termination, DNA replication and damage responses and genome stability. Most of the previous methods for genome-wide R-loop detection are based on immunoprecipitation using the monoclonal antibody S9.6 (which recognizes and binds to DNA:RNA hybrids in a non-sequence-specific manner) combined with high-throughput profiling such as tilling array hybridization and next-generation sequencing. |