Anti-DMTF1 Antibody (CAB17067)
- SKU:
- CAB17067
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
| 抗体名: | Anti-DMTF1 Antibody |
| 抗体コード: | CAB17067 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 561-760 of human DMTF1 (NP_066968.3). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 561-760 of human DMTF1 (NP_066968.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VTVQ CHTP RVII QTVA TEDI TSSI SQAE LTVD SDIQ SSDF PEPP DALE ADTF PDEI HHPK MTVE PSFN DAHV SKFS DQNS TELM NSVM VRTE EEIS DTDL KQEE SPSD LASA YVTE GLES PTIE EQVD QTID DETI LIVP SPHG FIQA SDVI DTES VLPL TTLT DPIL QHHQ EESN IIGS SLGS PVSE DSKD VEDL VNCH |
| 遺伝子ID: | 9988 |
| Uniprot: | Q9Y222 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | Refer to figures |
| 同義語: | DMTF1, DMP1, DMTF, MRUL, hDMP1 |
| バックグラウンド: | This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | DMTF1: Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest. Binds to the consensus sequence 5'-CCCG[GT]ATGT-3'. Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1. Belongs to the DMTF1 family. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding; Tumor suppressor; Cell cycle regulation Chromosomal Location of Human Ortholog: 7q21 Cellular Component: nucleoplasm; cytoplasm; nucleus Molecular Function:DNA binding; chromatin binding; transcription factor activity Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; cell cycle |
| NCBI Summary: | This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008] |
| UniProt Code: | Q9Y222 |
| NCBI GenInfo Identifier: | 74762040 |
| NCBI Gene ID: | 9988 |
| NCBI Accession: | Q9Y222.1 |
| UniProt Secondary Accession: | Q9Y222,Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3 B2RBE1, B4DJS5, |
| UniProt Related Accession: | Q9Y222 |
| Molecular Weight: | 74,878 Da |
| NCBI Full Name: | Cyclin-D-binding Myb-like transcription factor 1 |
| NCBI Synonym Full Names: | cyclin D binding myb-like transcription factor 1 |
| NCBI Official Symbol: | DMTF1 |
| NCBI Official Synonym Symbols: | DMP1; DMTF; MRUL; hDMP1 |
| NCBI Protein Information: | cyclin-D-binding Myb-like transcription factor 1; hDMTF1; cyclin D-binding Myb-like protein; cyclin-D-interacting Myb-like protein 1 |
| UniProt Protein Name: | Cyclin-D-binding Myb-like transcription factor 1 |
| UniProt Synonym Protein Names: | Cyclin-D-interacting Myb-like protein 1; hDMP1 |
| Protein Family: | Cyclin-D-binding Myb-like transcription factor |
| UniProt Gene Name: | DMTF1 |
| UniProt Entry Name: | DMTF1_HUMAN |
 | Western blot analysis of extracts of HT-29 cells, using DMTF1 antibody (CAB17067) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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