Anti-DMAP1 Antibody (CAB19281)

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SKU:
CAB19281
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
DMAP1
Synonyms:
DNMAP1
Synonyms:
DNMTAP1
Synonyms:
EAF2
Synonyms:
MEAF2
Synonyms:
SWC4
Synonyms:
DNA methyltransferase 1-associated protein 1
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Description

抗体名:DMAP1 Rabbit mAb
抗体コード:CAB19281
サイズ:20uL, 50uL, 100uL
同義語:DMAP1, DNMAP1, DNMTAP1, EAF2, MEAF2, SWC4, DNA methyltransferase 1-associated protein 1
申し込み:WB
反応性:Human, Mouse, Rat
宿主種:Rabbit
免疫原:Recombinant protein of human DMAP1.
申し込み:WB
推奨される希釈:WB 1:500 - 1:2000
反応性:Human, Mouse, Rat
免疫原:Recombinant protein of human DMAP1.
精製方法:Affinity purification
保管所:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:Email for sequence
遺伝子ID:55929
Uniprot:Q9NPF5
セルラーロケーション:Cytoplasm, Nucleus
計算された分子量:53kDa
観察された分子量:Refer to figures
UniProt Protein Function:Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity.
NCBI Summary:This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
UniProt Code:Q9NPF5
NCBI GenInfo Identifier:78000211
NCBI Gene ID:55929
NCBI Accession:NP_001029195.1
UniProt Secondary Accession:Q9NPF5,Q0JSM4, Q5TG41, Q7Z3H7, Q9H0S8, Q9P2C2, A8K001 D3DPY8,
UniProt Related Accession:Q9NPF5
Molecular Weight:52,993 Da
NCBI Full Name:DNA methyltransferase 1-associated protein 1
NCBI Synonym Full Names:DNA methyltransferase 1 associated protein 1
NCBI Official Symbol:DMAP1  
NCBI Official Synonym Symbols:EAF2; SWC4; MEAF2; DNMAP1; DNMTAP1  
NCBI Protein Information:DNA methyltransferase 1-associated protein 1
UniProt Protein Name:DNA methyltransferase 1-associated protein 1
Protein Family:DNA methyltransferase 1-associated protein
UniProt Gene Name:DMAP1  
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