Anti-DLX3 Antibody (CAB13972)
- SKU:
- CAB13972
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-DLX3 Antibody |
| 抗体コード: | CAB13972 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human DLX3 (NP_005211.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human DLX3 (NP_005211.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MSGS FDRK LSSI LTDI SSSL SCHA GSKD SPTL PESS VTDL GYYS APQH DYYS GQPY GQTV NPYT YHHQ FNLN GLAG TGAY SPKS EYTY GASY RQYG AYRE QPLP AQDP VSVK EEPE AEVR |
| 遺伝子ID: | 1747 |
| Uniprot: | O60479 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 31kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | DLX3, AI4, TDO |
| バックグラウンド: | Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. Trichodentoosseous syndrome (TDO), an autosomal dominant condition, has been correlated with DLX3 gene mutation. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 17. Mutations in this gene have been associated with the autosomal dominant conditions trichodentoosseous syndrome and amelogenesis imperfecta with taurodontism. |
| UniProt Protein Function: | DLX3: Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis. Defects in DLX3 are a cause of trichodentoosseous syndrome (TDO). TDO is an autosomal dominant syndrome characterized by enamel hypoplasia and hypocalcification with associated strikingly curly hair. Defects in DLX3 are the cause of amelogenesis imperfecta type 4 (AI4); also known as amelogenesis imperfecta hypomaturation-hypoplastic type with taurodontism. AI4 is an autosomal dominant defect of enamel formation associated with enlarged pulp chambers. Belongs to the distal-less homeobox family. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 17q21.33 Molecular Function:transcription factor activity Disease: Amelogenesis Imperfecta, Type Iv; Trichodentoosseous Syndrome |
| NCBI Summary: | Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. Trichodentoosseous syndrome (TDO), an autosomal dominant condition, has been correlated with DLX3 gene mutation. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 17. Mutations in this gene have been associated with the autosomal dominant conditions trichodentoosseous syndrome and amelogenesis imperfecta with taurodontism. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O60479 |
| NCBI GenInfo Identifier: | 3913487 |
| NCBI Gene ID: | 1747 |
| NCBI Accession: | O60479.1 |
| UniProt Secondary Accession: | O60479,B3KQL6, |
| UniProt Related Accession: | O60479 |
| Molecular Weight: | 31,738 Da |
| NCBI Full Name: | Homeobox protein DLX-3 |
| NCBI Synonym Full Names: | distal-less homeobox 3 |
| NCBI Official Symbol: | DLX3 |
| NCBI Official Synonym Symbols: | AI4; TDO |
| NCBI Protein Information: | homeobox protein DLX-3 |
| UniProt Protein Name: | Homeobox protein DLX-3 |
| Protein Family: | Distal-less-like protein |
| UniProt Gene Name: | DLX3 |
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