Anti-DLK1 Antibody (CAB6578)
- SKU:
- CAB6578
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-DLK1 Antibody |
抗体コード: | CAB6578 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 83-383 of human DLK1 (NP_003827.3). |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
反応性: | Human, Mouse |
ポジティブサンプル: | Mouse heart |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 83-383 of human DLK1 (NP_003827.3). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | ELCD RDVR ACSS APCA NNGT CVSL DDGL YECS CAPG YSGK DCQK KDGP CVIN GSPC QHGG TCVD DEGR ASHA SCLC PPGF SGNF CEIV ANSC TPNP CEND GVCT DIGG DFRC RCPA GFID KTCS RPVT NCAS SPCQ NGGT CLQH TQVS YECL CKPE FTGL TCVK KRAL SPQQ VTRL PSGY GLAY RLTP GVHE LPVQ QPEH RILK VSMK ELNK KTPL LTEG QAIC FTIL GVLT SLVV LGTV GIVF LNKC ETWV SNLR YNHM LRKK KNLL LQYN SGED LAVN IIFP EKID MTTF SKEA GDEE I |
遺伝子ID: | 8788 |
Uniprot: | P80370 |
セルラーロケーション: | Membrane, Single-pass type I membrane protein |
計算された分子量: | 33kDa/41kDa |
観察された分子量: | 45KDa |
同義語: | DLK1, DLK, DLK-1, Delta1, FA1, PREF1, Pref-1, ZOG, pG2 |
バックグラウンド: | This gene encodes a transmembrane protein that contains multiple epidermal growth factor repeats that functions as a regulator of cell growth. The encoded protein is involved in the differentiation of several cell types including adipocytes. This gene is located in a region of chromosome 14 frequently showing unparental disomy, and is imprinted and expressed from the paternal allele. A single nucleotide variant in this gene is associated with child and adolescent obesity and shows polar overdominance, where heterozygotes carrying an active paternal allele express the phenotype, while mutant homozygotes are normal. |
UniProt Protein Function: | DLK1: May have a role in neuroendocrine differentiation. Monomer. Found within the stromal cells in close contact to the vascular structure of placental villi, yolk sac, fetal liver, adrenal cortex and pancreas and in the beta cells of the islets of Langerhans in the adult pancreas. Found also in some forms of neuroendocrine lung tumor tissue. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 14q32 Cellular Component: extracellular space Biological Process: negative regulation of Notch signaling pathway |
NCBI Summary: | This gene encodes a transmembrane protein that contains multiple epidermal growth factor repeats that functions as a regulator of cell growth. The encoded protein is involved in the differentiation of several cell types including adipocytes. This gene is located in a region of chromosome 14 frequently showing unparental disomy, and is imprinted and expressed from the paternal allele. A single nucleotide variant in this gene is associated with child and adolescent obesity and shows polar overdominance, where heterozygotes carrying an active paternal allele express the phenotype, while mutant homozygotes are normal. [provided by RefSeq, Nov 2015] |
UniProt Code: | P80370 |
NCBI GenInfo Identifier: | 296439371 |
NCBI Gene ID: | 8788 |
NCBI Accession: | P80370.3 |
UniProt Secondary Accession: | P80370,P15803, Q96DW5, |
UniProt Related Accession: | P80370 |
Molecular Weight: | 33,067 Da |
NCBI Full Name: | Protein delta homolog 1 |
NCBI Synonym Full Names: | delta like non-canonical Notch ligand 1 |
NCBI Official Symbol: | DLK1 |
NCBI Official Synonym Symbols: | DLK; FA1; ZOG; pG2; DLK-1; PREF1; Delta1; Pref-1 |
NCBI Protein Information: | protein delta homolog 1 |
UniProt Protein Name: | Protein delta homolog 1 |
UniProt Synonym Protein Names: | pG2 |
Protein Family: | Protein |
UniProt Gene Name: | DLK1 |
UniProt Entry Name: | DLK1_HUMAN |
View AllClose