Anti-DISP1 Antibody (CAB14946)
- SKU:
- CAB14946
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-DISP1 Antibody |
抗体コード: | CAB14946 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1325-1524 of human DISP1 (NP_116279.2). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human |
ポジティブサンプル: | HT-29, HeLa |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1325-1524 of human DISP1 (NP_116279.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | FVHP ITHI HHCP CLQG RVKP AGMQ NSLP RNFF LHPV QHIQ AQEK IGKT NVHS LQRS IEEH LPKM AEPS SFVC RSTG SLLK TCCD PENK QREL CKNR DVSN LESS GGTE NKAG GKVE LSLS QTDA SVNS EHFN QNEP KVLF NHLM GEAG CRSC PNNS QSCG RIVR VKCN SVDC QMPN MEAN VPAV LTHS ELSG ESLL IKTL |
遺伝子ID: | 84976 |
Uniprot: | Q96F81 |
セルラーロケーション: | Membrane, Multi-pass membrane protein |
計算された分子量: | 170kDa |
観察された分子量: | 180kDa |
同義語: | DISP1, DISPA |
バックグラウンド: | The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo. |
UniProt Protein Function: | Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause a increase in SHH secretion (PubMed:22902404). |
NCBI Summary: | The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q96F81 |
NCBI GenInfo Identifier: | 25952134 |
NCBI Gene ID: | 84976 |
NCBI Accession: | NP_116279.2 |
UniProt Secondary Accession: | Q96F81,Q8N7C2, Q96I92, Q9H698, Q9H8H9, Q9UFA2, |
UniProt Related Accession: | Q96F81 |
Molecular Weight: | 167 |
NCBI Full Name: | protein dispatched homolog 1 isoform 1 |
NCBI Synonym Full Names: | dispatched RND transporter family member 1 |
NCBI Official Symbol: | DISP1 |
NCBI Official Synonym Symbols: | DISPA |
NCBI Protein Information: | protein dispatched homolog 1 |
UniProt Protein Name: | Protein dispatched homolog 1 |
Protein Family: | Protein dispatched |
UniProt Gene Name: | DISP1 |
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