Anti-DIRAS3 Antibody (CAB7950)
- SKU:
- CAB7950
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-DIRAS3 Antibody |
| 抗体コード: | CAB7950 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-229 of human DIRAS3 (NP_004666.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | NIH/3T3, Mouse liver, Mouse kidney, Rat liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-229 of human DIRAS3 (NP_004666.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MGNA SFGS KEQK LLKR LRLL PALL ILRA FKPH RKIR DYRV VVVG TAGV GKST LLHK WASG NFRH EYLP TIEN TYCQ LLGC SHGV LSLH ITDS KSGD GNRA LQRH VIAR GHAF VLVY SVTK KETL EELK AFYE LICK IKGN NLHK FPIV LVGN KSDD THRE VALN DGAT CAME WNCA FMEI SAKT DVNV QELF HMLL NYKK KPTT GLQE PEKK SQMP NTTE KLLD KCII M |
| 遺伝子ID: | 9077 |
| Uniprot: | O95661 |
| セルラーロケーション: | Cell membrane, Cytoplasmic side, Lipid-anchor |
| 計算された分子量: | 25kDa |
| 観察された分子量: | 30kDa |
| 同義語: | DIRAS3, ARHI, NOEY2 |
| バックグラウンド: | This gene encodes a member of the ras superfamily. This gene is imprinted gene with monoallelic expression of the paternal allele which is associated with growth suppression. The encoded protein acts as a tumor suppressor whose function is abrogated in many ovarian and breast cancers. This protein may also play a role autophagy in certain cancer cells by regulating the autophagosome initiation complex. |
| UniProt Protein Function: | DIRAS3: a member of the ras superfamily, and is expressed in normal ovarian and breast epithelial cells, but not in ovarian and breast cancers. It is an imprinted gene, with monoallelic expression of the paternal allele, which is associated with growth suppression. Thus, this gene appears to be a putative tumor suppressor gene whose function is abrogated in ovarian and breast cancers. [provided by RefSeq, Oct 2010] |
| UniProt Protein Details: | Protein type:G protein, monomeric; G protein; G protein, monomeric, di-Ras Chromosomal Location of Human Ortholog: 1p31 Cellular Component: plasma membrane Molecular Function:GTPase activity; protein binding; GTP binding Biological Process: genetic imprinting; small GTPase mediated signal transduction; regulation of cyclin-dependent protein kinase activity |
| UniProt Code: | O95661 |
| NCBI GenInfo Identifier: | 49456739 |
| NCBI Gene ID: | |
| NCBI Accession: | CAG46690.1 |
| UniProt Secondary Accession: | O95661,B3KMP3, |
| Molecular Weight: | 25 kDa |
| NCBI Full Name: | ARHI, partial |
| UniProt Protein Name: | GTP-binding protein Di-Ras3 |
| UniProt Synonym Protein Names: | Distinct subgroup of the Ras family member 3; Rho-related GTP-binding protein RhoI |
| UniProt Gene Name: | DIRAS3 |
| UniProt Entry Name: | DIRA3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using DIRAS3 antibody (CAB7950) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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