Anti-DGKQ Antibody (CAB3825)
- SKU:
- CAB3825
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-DGKQ Antibody |
抗体コード: | CAB3825 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 683-942 of human DGKQ (NP_001338.2). |
申し込み: | WB IHC |
推奨希釈: | WB 1:200 - 1:2000 IHC 1:50 - 1:200 |
反応性: | Human, Mouse |
ポジティブサンプル: | HeLa, K-562, MCF-7, Mouse brain, Mouse kidney |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 683-942 of human DGKQ (NP_001338.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | GRVL RWGA GYSG EDPF SVLL SVDE ADAV LMDR WTIL LDAH EAGS AEND TADA EPPK IVQM SNYC GIGI DAEL SLDF HQAR EEEP GKFT SRLH NKGV YVRV GLQK ISHS RSLH KQIR LQVE RQEV ELPS IEGL IFIN IPSW GSGA DLWG SDSD TRFE KPRM DDGL LEVV GVTG VVHM GQVQ GGLR SGIR IAQG SYFR VTLL KATP VQVD GEPW VQAP GHMI ISAA GPKV HMLR KAKQ KPRR AGTT RDAR ADAA PAPE SDPR |
遺伝子ID: | 1609 |
Uniprot: | P52824 |
セルラーロケーション: | Cell membrane, Cytoplasm, Nucleus, Nucleus speckle, cytoskeleton |
計算された分子量: | 101kDa |
観察された分子量: | 101kDa |
同義語: | DGKQ, DAGK, DAGK4, DAGK7 |
バックグラウンド: | The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. |
UniProt Protein Function: | DGKQ: Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of protein kinase C by controlling the balance between these two signaling lipids. Activated in the nucleus in response to alpha-thrombin and nerve growth factor. May be involved in cAMP- induced activation of NR5A1 and subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically with NR5A1 on CYP17 transcriptional activity. Belongs to the eukaryotic diacylglycerol kinase family. |
UniProt Protein Details: | Protein type:EC 2.7.1.107; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - glycerolipid; Motility/polarity/chemotaxis; Kinase, lipid Chromosomal Location of Human Ortholog: 4p16.3 Cellular Component: cytoplasm; cytoskeleton; cytosol; nuclear speck; nucleus; plasma membrane Molecular Function:diacylglycerol kinase activity; kinase binding; phospholipase binding; protein binding; transcription activator binding Biological Process: cAMP-mediated signaling; G-protein coupled receptor protein signaling pathway; platelet activation; regulation of transcription from RNA polymerase II promoter; response to ATP |
NCBI Summary: | The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. [provided by RefSeq, Jul 2008] |
UniProt Code: | P52824 |
NCBI GenInfo Identifier: | 257051005 |
NCBI Gene ID: | 1609 |
NCBI Accession: | P52824.2 |
UniProt Secondary Accession: | P52824,Q6P3W4, |
UniProt Related Accession: | P52824 |
Molecular Weight: | 101,155 Da |
NCBI Full Name: | Diacylglycerol kinase theta |
NCBI Synonym Full Names: | diacylglycerol kinase theta |
NCBI Official Symbol: | DGKQ |
NCBI Official Synonym Symbols: | DAGK; DAGK4; DAGK7 |
NCBI Protein Information: | diacylglycerol kinase theta |
UniProt Protein Name: | Diacylglycerol kinase theta |
UniProt Synonym Protein Names: | Diglyceride kinase theta; DGK-theta |
Protein Family: | Diacylglycerol kinase |
UniProt Gene Name: | DGKQ |
UniProt Entry Name: | DGKQ_HUMAN |
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