Anti-DES Antibody (CAB10838)
- SKU:
- CAB10838
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-DES Antibody |
| 抗体コード: | CAB10838 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 121-470 of human DES (NP_001918.3). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HeLa |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 121-470 of human DES (NP_001918.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | NYIE KVRF LEQQ NAAL AAEV NRLK GREP TRVA ELYE EELR ELRR QVEV LTNQ RARV DVER DNLL DDLQ RLKA KLQE EIQL KEEA ENNL AAFR ADVD AATL ARID LERR IESL NEEI AFLK KVHE EEIR ELQA QLQE QQVQ VEMD MSKP DLTA ALRD IRAQ YETI AAKN ISEA EEWY KSKV SDLT QAAN KNND ALRQ AKQE MMEY RHQI QSYT CEID ALKG TNDS LMRQ MREL EDRF ASEA SGYQ DNIA RLEE EIRH LKDE MARH LREY QDLL NVKM ALDV EIAT YRKL LEGE ESRI NLPI QTYS ALNF RETS PEQR GSEV HTKK TVMI KTIE TRDG EVVS EATQ QQHE VL |
| 遺伝子ID: | 1674 |
| Uniprot: | P17661 |
| セルラーロケーション: | Cell membrane, Cytoplasm, sarcolemma |
| 計算された分子量: | 53kDa |
| 観察された分子量: | 54kDa |
| 同義語: | DES, CSM1, CSM2, LGMD2R, desmin, Desmin |
| バックグラウンド: | This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. |
| UniProt Protein Function: | desmin: a class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cytoskeletal Chromosomal Location of Human Ortholog: 2q35 Cellular Component: intermediate filament; fascia adherens; cytosol; neuromuscular junction; Z disc; sarcolemma Molecular Function:identical protein binding; protein binding; structural constituent of cytoskeleton; cytoskeletal protein binding Biological Process: muscle contraction; cytoskeleton organization and biogenesis; regulation of heart contraction; muscle filament sliding Disease: Cardiomyopathy, Dilated, 1i; Scapuloperoneal Syndrome, Neurogenic, Kaeser Type; Myopathy, Myofibrillar, 1; Muscular Dystrophy, Limb-girdle, Type 2r |
| NCBI Summary: | This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P17661 |
| NCBI GenInfo Identifier: | 6686280 |
| NCBI Gene ID: | 1674 |
| NCBI Accession: | P17661.3 |
| UniProt Secondary Accession: | P17661,Q15787, Q549R7, Q549R8, Q549R9, Q8IZR1, Q8IZR6 Q8NES2, Q8NEU6, Q8TAC4, Q8TCX2, Q8TD99, |
| UniProt Related Accession: | P17661 |
| Molecular Weight: | |
| NCBI Full Name: | Desmin |
| NCBI Synonym Full Names: | desmin |
| NCBI Official Symbol: | DES |
| NCBI Official Synonym Symbols: | CSM1; CSM2; LGMD2R |
| NCBI Protein Information: | desmin; mutant desmin p.K241E; intermediate filament protein |
| UniProt Protein Name: | Desmin |
| Protein Family: | Desmin |
| UniProt Gene Name: | DES |
| UniProt Entry Name: | DESM_HUMAN |
 | Western blot analysis of extracts of HeLa cells, using DES antibody (CAB10838). |
 | Immunohistochemistry of paraffin-embedded human stomach using DES antibody (CAB10838) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat ovary using DES antibody (CAB10838) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse heart using DES antibody (CAB10838) at dilution of 1:100 (40x lens). |
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