Anti-DENND5A Antibody (CAB17662)
- SKU:
- CAB17662
- Product type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-DENND5A Antibody |
| 抗体コード: | CAB17662 |
| 抗体サイズ: | 20uL, 50 uL |
| 申し込み: | WB |
| 反応性: | Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1150-1240 of human DENND5A (NP_056028.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Rat |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1150-1240 of human DENND5A (NP_056028.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | AFQH GFKS PRLF KNVF IWDF LEKA QTYY ETLE KNEV VPEE NWHT RARN FCRF VTAI NNTP RNIG KDGK FQML VCLG ARDH LLHH WIAL LAD |
| 遺伝子ID: | 23258 |
| Uniprot: | Q6IQ26 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | Refer to figures |
| 同義語: | EIEE49, RAB6IP1, DENND5A |
| バックグラウンド: | This gene encodes a DENN-domain-containing protein that functions as a RAB-activating guanine nucleotide exchange factor (GEF). This protein catalyzes the conversion of GDP to GTP and thereby converts inactive GDP-bound Rab proteins into their active GTP-bound form. The encoded protein is recruited by RAB6 onto Golgi membranes and is therefore referred to as RAB6-interacting protein 1. This protein binds with RAB39 as well. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene are associated with early infantile epileptic encephalopathy-49. [provided by RefSeq, Feb 2017] |
| UniProt Protein Function: | Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Involved in the negative regulation of neurite outgrowth. |
| NCBI Summary: | This gene encodes a DENN-domain-containing protein that functions as a RAB-activating guanine nucleotide exchange factor (GEF). This protein catalyzes the conversion of GDP to GTP and thereby converts inactive GDP-bound Rab proteins into their active GTP-bound form. The encoded protein is recruited by RAB6 onto Golgi membranes and is therefore referred to as RAB6-interacting protein 1. This protein binds with RAB39 as well. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene are associated with early infantile epileptic encephalopathy-49. [provided by RefSeq, Feb 2017] |
| UniProt Code: | Q6IQ26 |
| NCBI GenInfo Identifier: | 343098489 |
| NCBI Gene ID: | 23258 |
| NCBI Accession: | NP_001230183.1 |
| UniProt Secondary Accession: | Q6IQ26,Q96GN3, Q9H6U7, Q9UFV0, Q9UPR1, B4DJ15, E9PS91 |
| UniProt Related Accession: | Q6IQ26 |
| Molecular Weight: | 141 |
| NCBI Full Name: | DENN domain-containing protein 5A isoform 2 |
| NCBI Synonym Full Names: | DENN domain containing 5A |
| NCBI Official Symbol: | DENND5A |
| NCBI Official Synonym Symbols: | EIEE49; RAB6IP1 |
| NCBI Protein Information: | DENN domain-containing protein 5A |
| UniProt Protein Name: | DENN domain-containing protein 5A |
| UniProt Synonym Protein Names: | Rab6-interacting protein 1; Rab6IP1 |
| UniProt Gene Name: | DENND5A |