Anti-DENND1A Antibody (CAB10758)
- SKU:
- CAB10758
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-DENND1A Antibody |
| 抗体コード: | CAB10758 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 270-527 of human DENND1A (NP_079096.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 270-527 of human DENND1A (NP_079096.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VDTN TLET PFDD LQSL PNDV ISSL KNRL KKVS TTTG DGVA RAFL KAQA AFFG SYRN ALKI EPEE PITF CEEA FVSH YRSG AMRQ FLQN ATQL QLFK QFID GRLD LLNS GEGF SDVF EEEI NMGE YAGS DKLY HQWL STVR KGSG AILN TVKT KANP AMKT VYKF AKDH AKMG IKEV KNRL KQKD IAEN GCAP TPEE QLPK TAPS PLVE AKDP KLRE DRRP ITVH FGQV RPPR PHVV KRPK SNIA VEGR RTSV PSPE QN |
| 遺伝子ID: | 57706 |
| Uniprot: | Q8TEH3 |
| セルラーロケーション: | Cell junction, Cytoplasmic vesicle, Peripheral membrane protein, clathrin-coated vesicle membrane, presynaptic cell membrane, synapse |
| 計算された分子量: | 52kDa/56kDa/59kDa/63kDa/110kDa/111kDa |
| 観察された分子量: | Refer to Figures |
| 同義語: | DENND1A, FAM31A, KIAA1608 |
| バックグラウンド: |
| UniProt Protein Function: | DENND1A: a guanine nucleotide exchange factor (GEF) associated with clathrin-coated vesicle and presynaptic membranes. Regulates clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles. Interacts with ITSN1 AND SH3GL2. Interacts with RAB35. Interacts with clathrin and with the adapter protein complex 2, AP-2. Localizes to clathrin patches at the plasma membrane and activatesRab35 in an endocytic pathway trafficking Shiga toxin to the trans-Golgi network. 7 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:GEF; GEF, Rab; Vesicle Chromosomal Location of Human Ortholog: 9q33.3 Cellular Component: clathrin coated vesicle membrane; clathrin-coated vesicle; cytosol; intracellular membrane-bound organelle; nucleoplasm Molecular Function:phosphatidylinositol 3-phosphate binding; Rab guanyl-nucleotide exchange factor activity Biological Process: endocytic recycling; endocytosis; regulation of Rab protein signal transduction |
| NCBI Summary: | Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010] |
| UniProt Code: | Q8TEH3 |
| NCBI GenInfo Identifier: | 109825594 |
| NCBI Gene ID: | 57706 |
| NCBI Accession: | Q8TEH3.2 |
| UniProt Secondary Accession: | Q8TEH3,Q05C88, Q5VWF0, Q6PJZ5, Q8IVD6, Q9H796, A8MZA3 B1AM80, B7Z3C8, B7Z669, D3PFD3, |
| UniProt Related Accession: | Q8TEH3 |
| Molecular Weight: | 111kDa |
| NCBI Full Name: | DENN domain-containing protein 1A |
| NCBI Synonym Full Names: | DENN domain containing 1A |
| NCBI Official Symbol: | DENND1A |
| NCBI Official Synonym Symbols: | FAM31A; KIAA1608 |
| NCBI Protein Information: | DENN domain-containing protein 1A |
| UniProt Protein Name: | DENN domain-containing protein 1A |
| UniProt Synonym Protein Names: | Connecdenn 1 |
| Protein Family: | DENN domain-containing protein |
| UniProt Gene Name: | DENND1A |
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