Anti-DEK Antibody (CAB5901)
- SKU:
- CAB5901
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-DEK Antibody |
| 抗体コード: | CAB5901 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-160 of human DEK (NP_003463.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | U-251MG, Mouse brain, Mouse kidney, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-160 of human DEK (NP_003463.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | KSLI VEGK REKK KVER LTMQ VSSL QREP FTIA QGKG QKLC EIER IHFF LSKK KTDE LRNL HKLL YNRP GTVS SLKK NVGQ FSGF PFEK GSVQ YKKK EEML KKFR NAML KSI |
| 遺伝子ID: | 7913 |
| Uniprot: | P35659 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 38kDa/42kDa |
| 観察された分子量: | 43kDa |
| 同義語: | DEK, D6S231E |
| バックグラウンド: | This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | DEK: a ubiquitous protein with a SAP domain, which is found in a variety of nuclear proteins involved in transcription, DNA repair, RNA processing or apoptotic chromatin degradation. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA and is also involved in splice site selection during mRNA processing. A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemias (AML). |
| UniProt Protein Details: | Protein type:Histone-binding; Oncoprotein; DNA-binding; DNA replication; RNA splicing Chromosomal Location of Human Ortholog: 6p22.3 Cellular Component: contractile fiber; nucleoplasm; nucleus Molecular Function:DNA binding; histone binding Biological Process: chromatin modification; positive regulation of gene expression, epigenetic; regulation of transcription from RNA polymerase II promoter; signal transduction; transcription from RNA polymerase II promoter; viral genome replication |
| NCBI Summary: | This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008] |
| UniProt Code: | P35659 |
| NCBI GenInfo Identifier: | 544150 |
| NCBI Gene ID: | 7913 |
| NCBI Accession: | P35659.1 |
| UniProt Related Accession: | P35659 |
| Molecular Weight: | |
| NCBI Full Name: | Protein DEK |
| NCBI Synonym Full Names: | DEK proto-oncogene |
| NCBI Official Symbol: | DEK |
| NCBI Official Synonym Symbols: | D6S231E |
| NCBI Protein Information: | protein DEK |
| UniProt Protein Name: | Protein DEK |
| Protein Family: | Protein |
| UniProt Gene Name: | DEK |
| UniProt Entry Name: | DEK_HUMAN |
 | Western blot analysis of extracts of various cell lines, using DEK antibody (CAB5901) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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