Anti-DEFA3 Antibody (CAB5340)
- SKU:
- CAB5340
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
| 抗体名: | Anti-DEFA3 Antibody |
| 抗体コード: | CAB5340 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-94 of human DEFA3 (NP_005208.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | MCF7, 22Rv1, SW480 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-94 of human DEFA3 (NP_005208.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | EPLQ ARAD EVAA APEQ IAAD IPEV VVSL AWDE SLAP KHPG SRKN MDCY CRIP ACIA GERR YGTC IYQG RLWA FCC |
| 遺伝子ID: | 1668 |
| Uniprot: | P59666 |
| セルラーロケーション: | Secreted |
| 計算された分子量: | 10kDa |
| 観察された分子量: | 13kDa |
| 同義語: | DEFA3, DEF3, HNP-3, HNP3, HP-3, HP3 |
| バックグラウンド: | Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 3, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 1 by only one amino acid. This gene and the gene encoding defensin, alpha 1 are both subject to copy number variation. |
| UniProt Protein Function: | defensin, alpha 3: Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. Belongs to the alpha-defensin family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 8p23.1 Cellular Component: extracellular space; Golgi lumen; extracellular region Biological Process: defense response to Gram-positive bacterium; estrogen receptor signaling pathway; innate immune response in mucosa; killing of cells of another organism; antibacterial humoral response; innate immune response; defense response to fungus; defense response to virus |
| NCBI Summary: | Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 3, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 1 by only one amino acid. This gene and the gene encoding defensin, alpha 1 are both subject to copy number variation. [provided by RefSeq, Oct 2014] |
| UniProt Code: | P59666 |
| NCBI GenInfo Identifier: | 30316323 |
| NCBI Gene ID: | 1668 |
| NCBI Accession: | P59666.1 |
| UniProt Secondary Accession: | P59666,P11479, Q14125, |
| UniProt Related Accession: | P59666 |
| Molecular Weight: | 94 |
| NCBI Full Name: | Neutrophil defensin 3 |
| NCBI Synonym Full Names: | defensin, alpha 3, neutrophil-specific |
| NCBI Official Symbol: | DEFA3 |
| NCBI Official Synonym Symbols: | HP3; DEF3; HNP3; HP-3; HNP-3 |
| NCBI Protein Information: | neutrophil defensin 3; neutrophil peptide 3; defensin 3, neutrophil-specific |
| UniProt Protein Name: | Neutrophil defensin 3 |
| UniProt Synonym Protein Names: | Defensin, alpha 3; HNP-3; HP-3; HP3 |
| Protein Family: | Alpha-defensin |
| UniProt Gene Name: | DEFA3 |
| UniProt Entry Name: | DEF3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using DEFA3 antibody (CAB5340) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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