| UniProt Protein Function: | DDIT4: Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1. Promotes neuronal cell death. Up-regulated in fibroblasts upon ionizing radiation, via a TP53-dependent pathway. Up-regulated by TP63 in primary keratinocytes, and down-regulated during keratinocyte differentiation. Up-regulated upon DNA alkylation. Up-regulated by amyloid beta-peptide and retinoic acid. Up-regulated by hypoxia, via a PI3K and HIF1A-dependent but TP53/TP63-independent mechanism. Broadly expressed, with lowest levels in brain, skeletal muscle and intestine. Up-regulated in substantia nigra neurons from Parkinson disease patients. Belongs to the DDIT4 family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 10q22.1 Cellular Component: cytoplasm; cytosol; intracellular Biological Process: brain development; cell proliferation; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; negative regulation of peptidyl-serine phosphorylation; negative regulation of TOR signaling pathway; nerve growth factor receptor signaling pathway; neuron differentiation; neuron migration; response to hypoxia |
| UniProt Code: | Q9NX09 |
| NCBI GenInfo Identifier: | 74753036 |
| NCBI Gene ID: | 54541 |
| NCBI Accession: | Q9NX09.1 |
| UniProt Secondary Accession: | Q9NX09,Q9H0S3, |
| UniProt Related Accession: | Q9NX09 |
| Molecular Weight: | 25,371 Da |
| NCBI Full Name: | DNA damage-inducible transcript 4 protein |
| NCBI Synonym Full Names: | DNA damage inducible transcript 4 |
| NCBI Official Symbol: | DDIT4 |
| NCBI Official Synonym Symbols: | Dig2; REDD1; REDD-1 |
| NCBI Protein Information: | DNA damage-inducible transcript 4 protein |
| UniProt Protein Name: | DNA damage-inducible transcript 4 protein |
| UniProt Synonym Protein Names: | HIF-1 responsive protein RTP801; Protein regulated in development and DNA damage response 1; REDD-1 |
| Protein Family: | DNA damage-inducible transcript 4 protein |
| UniProt Gene Name: | DDIT4 |
| UniProt Entry Name: | DDIT4_HUMAN |
