Anti-DCTD Antibody (CAB5889)
- SKU:
- CAB5889
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-DCTD Antibody |
抗体コード: | CAB5889 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-178 of human DCTD (NP_001912.2). |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | SW620, Mouse heart, Rat heart |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-178 of human DCTD (NP_001912.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MSEV SCKK RDDY LEWP EYFM AVAF LSAQ RSKD PNSQ VGAC IVNS ENKI VGIG YNGM PNGC SDDV LPWR RTAE NKLD TKYP YVCH AELN AIMN KNST DVKG CSMY VALF PCNE CAKL IIQA GIKE VIFM SDKY HDSD EATA ARLL FNMA GVTF RKFI PKCS KIVI DFDS INSR PSQK LQ |
遺伝子ID: | 1635 |
Uniprot: | P32321 |
セルラーロケーション: | |
計算された分子量: | 20kDa/21kDa |
観察された分子量: | 23kDa |
同義語: | DCTD |
バックグラウンド: | The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for thymidylate synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | DCTD: catalyzes the deamination of dCMP to dUMP, thus providing the nucleotide substrate for thymidylate synthase. Allosteric enzyme whose activity is greatly influenced by the end products of its metabolic pathway, dCTP and dTTP. |
UniProt Protein Details: | Protein type:Nucleotide Metabolism - pyrimidine; EC 3.5.4.12; Hydrolase Chromosomal Location of Human Ortholog: 4q35.1 Cellular Component: cytosol Molecular Function:zinc ion binding; dCMP deaminase activity Biological Process: pyrimidine base metabolic process; nucleobase, nucleoside and nucleotide metabolic process; nucleotide biosynthetic process; pyrimidine nucleotide metabolic process; pyrimidine nucleoside biosynthetic process |
NCBI Summary: | The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for thymidylate synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | P32321 |
NCBI GenInfo Identifier: | 23503055 |
NCBI Gene ID: | 1635 |
NCBI Accession: | P32321.2 |
UniProt Secondary Accession: | P32321,Q5M7Z8, Q9BVD8, B2R836, D3DP49, D3DP50, |
UniProt Related Accession: | P32321 |
Molecular Weight: | 178 |
NCBI Full Name: | Deoxycytidylate deaminase |
NCBI Synonym Full Names: | dCMP deaminase |
NCBI Official Symbol: | DCTD |
NCBI Protein Information: | deoxycytidylate deaminase |
UniProt Protein Name: | Deoxycytidylate deaminase |
UniProt Synonym Protein Names: | dCMP deaminase |
Protein Family: | Deoxycytidylate deaminase |
UniProt Gene Name: | DCTD |
UniProt Entry Name: | DCTD_HUMAN |
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