Anti-DCP1A Antibody (CAB7376)
- SKU:
- CAB7376
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-DCP1A Antibody |
| 抗体コード: | CAB7376 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 303-582 of human DCP1A (NP_060873.4). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:20 - 1:50 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HepG2, Jurkat, Mouse brain, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 303-582 of human DCP1A (NP_060873.4). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | NEKH APTY TIPL SPVL SPTL PAEA PTAQ VPPS LPRN STMM QAVK TTPR QRSP LLNQ PVPE LSHA SLIA NQSP FRAP LNVT NTAG TSLP SVDL LQKL RLTP QHDQ IQTQ PLGK GAMV ASFS PAAG QLAT PESF IEPP SKTA AARV AASA SLSN MVLA PLQS MQQN QDPE VFVQ PKVL SSAI PVAG APLV TATT TAVS SVLL APSV FQQT VTRS SDLE RKAS SPSP LTIG TPES QRKP SIIL SKSQ LQDT LIHL IKND SSFL STLH EVYL QVLT KNKD NHNL |
| 遺伝子ID: | 55802 |
| Uniprot: | Q9NPI6 |
| セルラーロケーション: | Cytoplasm, Nucleus, P-body |
| 計算された分子量: | 59kDa/63kDa |
| 観察された分子量: | 70KDa |
| 同義語: | DCP1A, HSA275986, Nbla00360, SMAD4IP1, SMIF |
| バックグラウンド: | Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants. |
| UniProt Protein Function: | DCP1A: a decapping enzyme. Plays a role in general and regulated mRNA decay. Apparently plays a role in the nonsense-mediated decay pathway that rids cells of mRNAs containing premature termination codons. May function as a transactivator of SMAD4 that participates in TGF-beta signaling. |
| UniProt Protein Details: | Protein type:RNA processing; Transcription, coactivator/corepressor; EC 3.-.-.-; Hydrolase Chromosomal Location of Human Ortholog: 3p21.1 Cellular Component: cytosol; intracellular membrane-bound organelle; membrane; nucleus Molecular Function:enzyme activator activity; enzyme regulator activity; hydrolase activity; identical protein binding; mRNA binding; protein binding Biological Process: deadenylation-dependent decapping; deadenylation-independent decapping; gene expression; mRNA catabolic process, deadenylation-dependent decay; mRNA catabolic process, nonsense-mediated decay; positive regulation of catalytic activity; regulation of mRNA stability |
| NCBI Summary: | Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014] |
| UniProt Code: | Q9NPI6 |
| NCBI GenInfo Identifier: | 296434475 |
| NCBI Gene ID: | 55802 |
| NCBI Accession: | Q9NPI6.2 |
| UniProt Secondary Accession: | Q9NPI6,B4DHN9, U3KQM8, |
| UniProt Related Accession: | Q9NPI6 |
| Molecular Weight: | 59,361 Da |
| NCBI Full Name: | mRNA-decapping enzyme 1A |
| NCBI Synonym Full Names: | decapping mRNA 1A |
| NCBI Official Symbol: | DCP1A |
| NCBI Official Synonym Symbols: | SMIF; SMAD4IP1; HSA275986; Nbla00360 |
| NCBI Protein Information: | mRNA-decapping enzyme 1A |
| UniProt Protein Name: | mRNA-decapping enzyme 1A |
| UniProt Synonym Protein Names: | Smad4-interacting transcriptional co-activator; Transcription factor SMIF |
| Protein Family: | mRNA-decapping enzyme |
| UniProt Gene Name: | DCP1A |
| UniProt Entry Name: | DCP1A_HUMAN |
 | Western blot analysis of extracts of various cell lines, using DCP1A Rabbit pAb (CAB7376) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunofluorescence analysis of A549 cells using DCP1A antibody (CAB7376). Blue: DAPI for nuclear staining. |
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