Anti-DCLRE1A Antibody (CAB14312)
- SKU:
- CAB14312
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
| 抗体名: | Anti-DCLRE1A Antibody |
| 抗体コード: | CAB14312 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human DCLRE1A (NP_001258745.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | U-87MG, LO2, 293T, HeLa, A-549 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human DCLRE1A (NP_001258745.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MLED ISEE DIWE YKSK RKPK RVDP NNGS KNIL KSVE KATD GKYQ SKRS RNRK RAAE AKEV KDHE VPLG NAGC QTSV ASSQ NSSC GDGI QQTQ DKET TPGK LCRT QKSQ HVSP KIRP VYDG YCPN CQMP FSSL IGQT PRWH VFEC LDSP PRSE TECP DGLL CTST IPFH YKRY THFL LAQS RAGD HPFS SPSP ASGG SFSE TKSG VLCS LEER WSSY QNQT DNSV SNDP LLMT QYFK KSPS LTEA SEKI STHI QTSQ QALQ FTDF VEND KLVG VALR LANN SEHI NLPL PEND FSDC EISY |
| 遺伝子ID: | 9937 |
| Uniprot: | Q6PJP8 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 116kDa |
| 観察された分子量: | 116kDa |
| 同義語: | DCLRE1A, PSO2, SNM1, SNM1A |
| バックグラウンド: | This gene encodes a conserved protein that is involved in the repair of DNA interstrand cross-links. DNA cross-links suppress transcription, replication, and DNA segregation. The encoded protein is a regulator of the mitotic cell cycle checkpoint. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | DCLRE1A: May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 10q25.1 Cellular Component: nucleolus; nucleus Biological Process: mitosis; cell division; nucleotide-excision repair |
| NCBI Summary: | This gene encodes a conserved protein that is involved in the repair of DNA interstrand cross-links. DNA cross-links suppress transcription, replication, and DNA segregation. The encoded protein is a regulator of the mitotic cell cycle checkpoint. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012] |
| UniProt Code: | Q6PJP8 |
| NCBI GenInfo Identifier: | 425871110 |
| NCBI Gene ID: | 9937 |
| NCBI Accession: | NP_001258745.1 |
| UniProt Secondary Accession: | Q6PJP8,Q14701, Q6P5Y3, Q6PKL4, D3DRC1, |
| UniProt Related Accession: | Q6PJP8 |
| Molecular Weight: | 116,400 Da |
| NCBI Full Name: | DNA cross-link repair 1A protein |
| NCBI Synonym Full Names: | DNA cross-link repair 1A |
| NCBI Official Symbol: | DCLRE1A |
| NCBI Official Synonym Symbols: | PSO2; SNM1; SNM1A |
| NCBI Protein Information: | DNA cross-link repair 1A protein; SNM1 homolog A; DNA-crosslink repair gene SNM1 |
| UniProt Protein Name: | DNA cross-link repair 1A protein |
| UniProt Synonym Protein Names: | SNM1 homolog A; hSNM1; hSNM1A |
| UniProt Gene Name: | DCLRE1A |
| UniProt Entry Name: | DCR1A_HUMAN |
 | Western blot analysis of extracts of various cell lines, using DCLRE1A antibody (CAB14312) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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