| バックグラウンド: | This gene encodes a proline-rich protein which interacts with the deleted in azoospermia (DAZ) and the deleted in azoospermia-like gene through the DAZ-like repeats. This protein also interacts with the transforming growth factor-beta signaling molecule SARA (Smad anchor for receptor activation), eukaryotic initiation factor 4G, and an E3 ubiquitinase that regulates its stability in splicing factor containing nuclear speckles. The encoded protein may function in various biological and pathological processes including spermatogenesis, cell signaling and transcription regulation, formation of stress granules during translation arrest, RNA splicing, and pathogenesis of multiple myeloma. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | DAZAP2: 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 12q12 Molecular Function:protein binding; WW domain binding |
| NCBI Summary: | This gene encodes a proline-rich protein which interacts with the deleted in azoospermia (DAZ) and the deleted in azoospermia-like gene through the DAZ-like repeats. This protein also interacts with the transforming growth factor-beta signaling molecule SARA (Smad anchor for receptor activation), eukaryotic initiation factor 4G, and an E3 ubiquitinase that regulates its stability in splicing factor containing nuclear speckles. The encoded protein may function in various biological and pathological processes including spermatogenesis, cell signaling and transcription regulation, formation of stress granules during translation arrest, RNA splicing, and pathogenesis of multiple myeloma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] |
| UniProt Code: | Q15038 |
| NCBI GenInfo Identifier: | 44887865 |
| NCBI Gene ID: | 9802 |
| NCBI Accession: | Q15038.1 |
| UniProt Secondary Accession: | Q15038,A8K254, B4DDT5, B4E1G3, C9JA96, C9JP84, E9PB45 F8VU62, |
| UniProt Related Accession: | Q15038 |
| Molecular Weight: | 22,823 Da |
| NCBI Full Name: | DAZ-associated protein 2 |
| NCBI Synonym Full Names: | DAZ associated protein 2 |
| NCBI Official Symbol: | DAZAP2 |
| NCBI Official Synonym Symbols: | PRTB |
| NCBI Protein Information: | DAZ-associated protein 2 |
| UniProt Protein Name: | DAZ-associated protein 2 |
| UniProt Synonym Protein Names: | Deleted in azoospermia-associated protein 2 |
| Protein Family: | DAZ-associated protein |
| UniProt Gene Name: | DAZAP2 |
| UniProt Entry Name: | DAZP2_HUMAN |
