Anti-DACH1 Antibody (CAB3823)
- SKU:
- CAB3823
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-DACH1 Antibody |
| 抗体コード: | CAB3823 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 450-570 of human DACH1 (NP_542937.2). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:200 - 1:2000 IHC 1:20 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 450-570 of human DACH1 (NP_542937.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | EGRR PGSH PSSH RSSS VSSS PART ESSS DRIP VHQN GLSM NQML MGLS PNVL PGPK EGDL AGHD MGHE SKRM HIEK DETP LSTP TARD SLDK LSLT GHGQ PLPP GFPS PFLF PDGL SSIE T |
| 遺伝子ID: | 1602 |
| Uniprot: | Q9UI36 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 52kDa/57kDa/73kDa/78kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | DACH1, DACH |
| バックグラウンド: | This gene encodes a chromatin-associated protein that associates with other DNA-binding transcription factors to regulate gene expression and cell fate determination during development. The protein contains a Ski domain that is highly conserved from Drosophila to human. Expression of this gene is lost in some forms of metastatic cancer, and is correlated with poor prognosis. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | DACH1: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin- dependent kinase inhibitors, including the p27Kip1 promoter. Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain. Belongs to the DACH/dachshund family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription factor; Motility/polarity/chemotaxis; DNA-binding Chromosomal Location of Human Ortholog: 13q22 Cellular Component: nucleoplasm; transcription factor complex; intracellular membrane-bound organelle; cytoplasm; nucleolus; nucleus Molecular Function:protein binding; DNA binding Biological Process: cell proliferation; development of primary female sexual characteristics; suckling behavior; negative regulation of fibroblast proliferation; respiratory gaseous exchange; negative regulation of transcription from RNA polymerase II promoter; transcriptional preinitiation complex assembly; negative regulation of cell migration |
| UniProt Code: | Q9UI36 |
| NCBI GenInfo Identifier: | 519668677 |
| NCBI Gene ID: | |
| NCBI Accession: | Q9UI36.3 |
| Molecular Weight: | |
| NCBI Full Name: | Dachshund homolog 1 |
| UniProt Protein Name: | Dachshund homolog 1 |
| Protein Family: | Dachshund |
| UniProt Gene Name: | DACH1 |
| UniProt Entry Name: | DACH1_HUMAN |
 | Immunohistochemistry of paraffin-embedded human colon carcinoma using DACH1 antibody (CAB3823) at dilution of 1:100 (40x lens). |
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