Anti-Cytokeratin-18 Mouse Monoclonal Antibody (CAB0389)
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- SKU:
- CAB0389
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Monkey
- Host Species:
- Mouse
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
| 抗体名: | Anti-Cytokeratin-18 Mouse Monoclonal Antibody |
| 抗体コード: | CAB0389 |
| 抗体サイズ: | 100µL |
| 申し込み: | WB ICC |
| 反応性: | Human, Monkey |
| 宿主種: | Mouse |
| 免疫原: | Recombinant protein of human KRT18 |
| 申し込み: | WB ICC |
| 推奨希釈: | WB 1:1000 - 1:4000 ICC 1:50 - 1:200 |
| 反応性: | Human, Monkey |
| ポジティブサンプル: | COS-7, HeLa, HT-29, LO2, A-549 |
| 免疫原: | Recombinant protein of human KRT18 |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 3875 |
| Uniprot: | P05783 |
| セルラーロケーション: | Cytoplasm, Nucleus, nucleolus, perinuclear region |
| 計算された分子量: | 48kDa |
| 観察された分子量: | 48kDa |
| 同義語: | KRT18, CK-18, CYK18, K18, keratin 18 |
| バックグラウンド: | KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. |
| UniProt Protein Function: | K18: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Keratin 18 and its filament partner keratin 8 are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Defects are a cause of cryptogenic cirrhosis. |
| UniProt Protein Details: | Protein type:Nucleolus; Cytoskeletal Chromosomal Location of Human Ortholog: 12q13 Cellular Component: cytoplasm; intermediate filament; keratin filament; microtubule organizing center; nucleolus; perinuclear region of cytoplasm Molecular Function:protein binding; structural molecule activity Biological Process: anatomical structure morphogenesis; cell cycle; Golgi to plasma membrane CFTR protein transport; intermediate filament cytoskeleton organization and biogenesis; negative regulation of apoptosis; tumor necrosis factor-mediated signaling pathway; viral reproduction Disease: Cirrhosis, Familial |
| NCBI Summary: | KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P05783 |
| NCBI GenInfo Identifier: | 125083 |
| NCBI Gene ID: | 3875 |
| NCBI Accession: | P05783.2 |
| UniProt Secondary Accession: | P05783,Q53G38, Q5U0N8, Q9BW26, |
| UniProt Related Accession: | P05783 |
| Molecular Weight: | |
| NCBI Full Name: | Keratin, type I cytoskeletal 18 |
| NCBI Synonym Full Names: | keratin 18 |
| NCBI Official Symbol: | KRT18 |
| NCBI Official Synonym Symbols: | K18; CK-18; CYK18 |
| NCBI Protein Information: | keratin, type I cytoskeletal 18 |
| UniProt Protein Name: | Keratin, type I cytoskeletal 18 |
| UniProt Synonym Protein Names: | Cell proliferation-inducing gene 46 protein; Cytokeratin-18; CK-18; Keratin-18; K18 |
| Protein Family: | Keratin |
| UniProt Gene Name: | KRT18 |
| UniProt Entry Name: | K1C18_HUMAN |
 | Western blot analysis of extracts of various cell lines, using Cytokeratin-18 antibody (CAB0389) at 1:2000 dilution. Secondary antibody: HRP Goat Anti-Mouse IgG (H+L) (CABS003) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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