Anti-Cytochrome c Antibody (CAB13430)[KO Validated]

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SKU:
CAB13430
Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
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Description

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抗体名:Anti-Cytochrome c Antibody [KO Validated]
抗体コード:CAB13430
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB IHC IF
反応性:Human, Mouse, Rat
宿主種:Rabbit
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 1-105 of human Cytochrome c (NP_061820.1).
申し込み:WB IHC IF
推奨希釈:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
反応性:Human, Mouse, Rat
ポジティブサンプル:293T, SH-SY5Y, BT-474
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 1-105 of human Cytochrome c (NP_061820.1).
精製方法:Affinity purification
ストレージバッファ:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:MGDV EKGK KIFI MKCS QCHT VEKG GKHK TGPN LHGL FGRK TGQA PGYS YTAA NKNK GIIW GEDT LMEY LENP KKYI PGTK MIFV GIKK KEER ADLI AYLK KATN E
遺伝子ID:54205
Uniprot:P99999
セルラーロケーション:Mitochondrion intermembrane space
計算された分子量:11kDa
観察された分子量:11KDa
同義語:CYCS, CYC, HCS, THC4, cytochrome c
バックグラウンド:This gene encodes a small heme protein that functions as a central component of the electron transport chain in mitochondria. The encoded protein associates with the inner membrane of the mitochondrion where it accepts electrons from cytochrome b and transfers them to the cytochrome oxidase complex. This protein is also involved in initiation of apoptosis. Mutations in this gene are associated with autosomal dominant nonsyndromic thrombocytopenia. Numerous processed pseudogenes of this gene are found throughout the human genome.
UniProt Protein Function:CYCS: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Belongs to the cytochrome c family.
UniProt Protein Details:

Protein type:Apoptosis; Oxidoreductase; Mitochondrial; Protein phosphatase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 7p15.3

Cellular Component: cytosol; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrion; nucleus; protein phosphatase type 2A complex

Molecular Function:electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity; heme binding; protein binding; protein serine/threonine phosphatase activity

Biological Process: caspase activation via cytochrome c; cellular respiration; mitochondrial electron transport, cytochrome c to oxygen; mitochondrial electron transport, ubiquinol to cytochrome c; mitochondrion organization and biogenesis; response to reactive oxygen species

Disease: Thrombocytopenia 4

NCBI Summary:This gene encodes a small heme protein that functions as a central component of the electron transport chain in mitochondria. The encoded protein associates with the inner membrane of the mitochondrion where it accepts electrons from cytochrome b and transfers them to the cytochrome oxidase complex. This protein is also involved in initiation of apoptosis. Mutations in this gene are associated with autosomal dominant nonsyndromic thrombocytopenia. Numerous processed pseudogenes of this gene are found throughout the human genome.[provided by RefSeq, Jul 2010]
UniProt Code:P99999
NCBI GenInfo Identifier:42560196
NCBI Gene ID:54205
NCBI Accession:P99999.2
UniProt Secondary Accession:P99999,P00001, Q6NUR2, Q6NX69, Q96BV4, A4D166, B2R4I1
UniProt Related Accession:P99999
Molecular Weight:11,749 Da
NCBI Full Name:Cytochrome c
NCBI Synonym Full Names:cytochrome c, somatic
NCBI Official Symbol:CYCS  
NCBI Official Synonym Symbols:CYC; HCS; THC4  
NCBI Protein Information:cytochrome c
UniProt Protein Name:Cytochrome c
Protein Family:Cytochrome
UniProt Gene Name:CYCS  
UniProt Entry Name:CYC_HUMAN
Anti-Cytochrome c Antibody [KO Validated] (CAB13430)Western blot analysis of extracts of various cell lines, using Cytochrome c Rabbit pAb (CAB13430) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
Anti-Cytochrome c Antibody [KO Validated] (CAB13430)Western blot analysis of extracts from normal (control) and Cytochrome c knockout (KO) 293T cells, using Cytochrome c antibody (CAB13430) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-Cytochrome c Antibody [KO Validated] (CAB13430)Immunohistochemistry of paraffin-embedded rat lung using Cytochrome c antibody (CAB13430) at dilution of 1:100 (40x lens).
Anti-Cytochrome c Antibody [KO Validated] (CAB13430)Immunohistochemistry of paraffin-embedded human tonsil using Cytochrome c antibody (CAB13430) at dilution of 1:100 (40x lens).
Anti-Cytochrome c Antibody [KO Validated] (CAB13430)Immunohistochemistry of paraffin-embedded human liver cancer using Cytochrome c antibody (CAB13430) at dilution of 1:100 (40x lens).
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