Anti-CYTH2 Antibody (CAB7035)
- SKU:
- CAB7035
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-CYTH2 Antibody |
| 抗体コード: | CAB7035 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 150-350 of human CYTH2 (NP_059431.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | A-549, MCF7, HepG2, Mouse ovary, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 150-350 of human CYTH2 (NP_059431.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | SFRL PGEA QKID RMME AFAQ RYCL CNPG VFQS TDTC YVLS FAVI MLNT SLHN PNVR DKPG LERF VAMN RGIN EGGD LPEE LLRN LYDS IRNE PFKI PEDD GNDL THTF FNPD REGW LLKL GGGR VKTW KRRW FILT DNCL YYFE YTTD KEPR GIIP LENL SIRE VDDP RKPN CFEL YIPN NKGQ LIKA CKTE ADGR VVEG N |
| 遺伝子ID: | 9266 |
| Uniprot: | Q99418 |
| セルラーロケーション: | Cell membrane, Cell projection, Cytoplasm, Peripheral membrane protein, growth cone |
| 計算された分子量: | 46kDa |
| 観察された分子量: | 47kDa |
| 同義語: | CYTH2, ARNO, CTS18, CTS18.1, PSCD2, PSCD2L, SEC7L, Sec7p-L, Sec7p-like |
| バックグラウンド: | The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | cytohesin 2: Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:GEFs; GEFs, ARF Chromosomal Location of Human Ortholog: 19q13.33 Cellular Component: membrane; cytoplasm; plasma membrane; trans-Golgi network Molecular Function:protein binding; lipid binding; ARF guanyl-nucleotide exchange factor activity Biological Process: regulation of cell adhesion; vesicle-mediated transport; endocytosis; regulation of ARF protein signal transduction; actin cytoskeleton organization and biogenesis; positive regulation of GTPase activity |
| NCBI Summary: | The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] |
| UniProt Code: | Q99418 |
| NCBI GenInfo Identifier: | 13124707 |
| NCBI Gene ID: | 9266 |
| NCBI Accession: | Q99418.2 |
| UniProt Related Accession: | Q99418 |
| Molecular Weight: | 46kDa |
| NCBI Full Name: | Cytohesin-2 |
| NCBI Synonym Full Names: | cytohesin 2 |
| NCBI Official Symbol: | CYTH2 |
| NCBI Official Synonym Symbols: | ARNO; CTS18; PSCD2; SEC7L; PSCD2L; CTS18.1; Sec7p-L; Sec7p-like; cytohesin-2 |
| NCBI Protein Information: | cytohesin-2 |
| UniProt Protein Name: | Cytohesin-2 |
| UniProt Synonym Protein Names: | ARF exchange factor; ARF nucleotide-binding site opener; Protein ARNO; PH, SEC7 and coiled-coil domain-containing protein 2 |
| Protein Family: | Cytohesin |
| UniProt Gene Name: | CYTH2 |
| UniProt Entry Name: | CYH2_HUMAN |
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