| UniProt Protein Function: | CYR61: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. Belongs to the CCN family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 1p22.3 Cellular Component: extracellular matrix; proteinaceous extracellular matrix Molecular Function:heparin binding; integrin binding; insulin-like growth factor binding; extracellular matrix binding Biological Process: anatomical structure morphogenesis; extracellular matrix organization and biogenesis; positive regulation of caspase activity; chemotaxis; intussusceptive angiogenesis; osteoblast differentiation; cell proliferation; positive regulation of osteoblast differentiation; cell-cell signaling; positive regulation of protein kinase activity; positive regulation of osteoblast proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; regulation of cell growth; cell adhesion; positive regulation of BMP signaling pathway; positive regulation of cell migration; negative regulation of apoptosis |
| NCBI Summary: | The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011] |
| UniProt Code: | O00622 |
| NCBI GenInfo Identifier: | 3023601 |
| NCBI Gene ID: | 3491 |
| NCBI Accession: | O00622.1 |
| UniProt Secondary Accession: | O00622,O14934, O43775, Q9BZL7, |
| UniProt Related Accession: | O00622 |
| Molecular Weight: | |
| NCBI Full Name: | Protein CYR61 |
| NCBI Synonym Full Names: | cysteine-rich, angiogenic inducer, 61 |
| NCBI Official Symbol: | CYR61 |
| NCBI Official Synonym Symbols: | CCN1; GIG1; IGFBP10 |
| NCBI Protein Information: | protein CYR61; IBP-10; IGFBP-10; CCN family member 1; IGF-binding protein 10; cysteine-rich, anigogenic inducer, 61; cysteine-rich heparin-binding protein 61; insulin-like growth factor-binding protein 10 |
| UniProt Protein Name: | Protein CYR61 |
| UniProt Synonym Protein Names: | CCN family member 1; Cysteine-rich angiogenic inducer 61; Insulin-like growth factor-binding protein 10; IBP-10; IGF-binding protein 10; IGFBP-10; Protein GIG1 |
| Protein Family: | Protein |
| UniProt Gene Name: | CYR61 |
| UniProt Entry Name: | CYR61_HUMAN |
