Anti-CYP3A7 Antibody (CAB10026)
- SKU:
- CAB10026
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-CYP3A7 Antibody |
抗体コード: | CAB10026 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 244-503 of human CYP3A7 (NP_000756.3). |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | A-549, HT-29, Mouse liver, Mouse lung, Rat liver |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 244-503 of human CYP3A7 (NP_000756.3). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | KVIS FLTK SVKQ IKEG RLKE TQKH RVDF LQLM IDSQ NSKD SETH KALS DLEL MAQS IIFI FAGY ETTS SVLS FIIY ELAT HPDV QQKV QKEI DTVL PNKA PPTY DTVL QLEY LDMV VNET LRLF PVAM RLER VCKK DVEI NGMF IPKG VVVM IPSY VLHH DPKY WTEP EKFL PERF SKKN KDNI DPYI YTPF GSGP RNCI GMRF ALVN MKLA LVRV LQNF SFKP CKET QIPL KLRF GGLL LTEK PIVL KAES RDET VSGA |
遺伝子ID: | 1551 |
Uniprot: | P24462 |
セルラーロケーション: | Endoplasmic reticulum membrane, Microsome membrane, Peripheral membrane protein |
計算された分子量: | 57kDa/61kDa |
観察された分子量: | 75kDa |
同義語: | CYP3A7, CP37, CYPIIIA7, P-450(HFL33), P-450111A7, P450-HFLA |
バックグラウンド: | This gene encodes a member of the cytochrome P450 superfamily of enzymes, which participate in drug metabolism and the synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. This gene is part of a cluster of related genes on chromosome 7q21.1. Naturally-occurring readthrough transcription occurs between this gene and the downstream CYP3A51P pseudogene and is represented by GeneID:100861540. |
UniProt Protein Function: | CYP3A7: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Belongs to the cytochrome P450 family. |
UniProt Protein Details: | Protein type:Xenobiotic Metabolism - metabolism by cytochrome P450; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Lipid Metabolism - linoleic acid; Xenobiotic Metabolism - drug metabolism - other enzymes; Cofactor and Vitamin Metabolism - retinol; EC 1.14.14.1 Chromosomal Location of Human Ortholog: 7q22.1 Cellular Component: endoplasmic reticulum membrane Molecular Function:iron ion binding; heme binding; oxygen binding; monooxygenase activity Biological Process: xenobiotic metabolic process |
NCBI Summary: | This gene encodes a member of the cytochrome P450 superfamily of enzymes, which participate in drug metabolism and the synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. This gene is part of a cluster of related genes on chromosome 7q21.1. Naturally-occurring readthrough transcription occurs between this gene and the downstream CYP3A51P pseudogene and is represented by GeneID:100861540. [provided by RefSeq, Jan 2015] |
UniProt Code: | P24462 |
NCBI GenInfo Identifier: | 608788370 |
NCBI Gene ID: | 1551 |
NCBI Accession: | NP_000756.3 |
UniProt Secondary Accession: | P24462,Q9H241, A4D288, |
UniProt Related Accession: | P24462 |
Molecular Weight: | 61,547 Da |
NCBI Full Name: | cytochrome P450 3A7 |
NCBI Synonym Full Names: | cytochrome P450, family 3, subfamily A, polypeptide 7 |
NCBI Official Symbol: | CYP3A7 |
NCBI Official Synonym Symbols: | CP37; CYPIIIA7; P450-HFLA; P-450111A7; P-450(HFL33) |
NCBI Protein Information: | cytochrome P450 3A7 |
UniProt Protein Name: | Cytochrome P450 3A7 |
UniProt Synonym Protein Names: | CYPIIIA7; Cytochrome P450-HFLA |
Protein Family: | Cytochrome |
UniProt Gene Name: | CYP3A7 |
UniProt Entry Name: | CP3A7_HUMAN |
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