Anti-CYP2F1 Antibody (CAB7550)
- SKU:
- CAB7550
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-CYP2F1 Antibody |
| 抗体コード: | CAB7550 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-290 of human CYP2F1 (NP_000765.2). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | SW620, BT-474, Mouse lung, Mouse liver, Rat liver, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-290 of human CYP2F1 (NP_000765.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | DYPA FFNF TKGN GIAF SSGD RWKV LRQF SIQI LRNF GMGK RSIE ERIL EEGS FLLA ELRK TEGE PFDP TFVL SRSV SNII CSVL FGSR FDYD DERL LTII RLIN DNFQ IMSS PWGE LYDI FPSL LDWV PGPH QRIF QNFK CLRD LIAH SVHD HQAS LDPR SPRD FIQC FLTK MAEE KEDP LSHF HMDT LLM |
| 遺伝子ID: | 1572 |
| Uniprot: | P24903 |
| セルラーロケーション: | Endoplasmic reticulum membrane, Microsome membrane, Peripheral membrane protein |
| 計算された分子量: | 36kDa/55kDa |
| 観察された分子量: | 46-54kDa |
| 同義語: | CYP2F1, C2F1, CYP2F, CYPIIF1 |
| バックグラウンド: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to dehydrogenate 3-methylindole, an endogenous toxin derived from the fermentation of tryptophan, as well as xenobiotic substrates such as naphthalene and ethoxycoumarin. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. |
| UniProt Protein Function: | CYP2F2: May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3- methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine. Belongs to the cytochrome P450 family. |
| UniProt Protein Details: | Protein type:Xenobiotic Metabolism - metabolism by cytochrome P450; EC 1.14.14.1; Oxidoreductase Chromosomal Location of Human Ortholog: 19q13.2 Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; cytoplasm Molecular Function:iron ion binding; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; arachidonic acid epoxygenase activity; steroid hydroxylase activity; oxygen binding; monooxygenase activity Biological Process: response to toxin; xenobiotic metabolic process; exogenous drug catabolic process; trichloroethylene metabolic process; epoxygenase P450 pathway; naphthalene metabolic process |
| NCBI Summary: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to dehydrogenate 3-methylindole, an endogenous toxin derived from the fermentation of tryptophan, as well as xenobiotic substrates such as naphthalene and ethoxycoumarin. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P24903 |
| NCBI GenInfo Identifier: | 259016202 |
| NCBI Gene ID: | 1572 |
| NCBI Accession: | P24903.2 |
| UniProt Related Accession: | P24903 |
| Molecular Weight: | |
| NCBI Full Name: | Cytochrome P450 2F1 |
| NCBI Synonym Full Names: | cytochrome P450 family 2 subfamily F member 1 |
| NCBI Official Symbol: | CYP2F1 |
| NCBI Official Synonym Symbols: | C2F1; CYP2F; CYPIIF1 |
| NCBI Protein Information: | cytochrome P450 2F1 |
| UniProt Protein Name: | Cytochrome P450 2F1 |
| UniProt Synonym Protein Names: | CYPIIF1 |
| UniProt Gene Name: | CYP2F1 |
| UniProt Entry Name: | CP2F1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CYP2F1 antibody (CAB7550) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded mouse lung using CYP2F1 antibody (CAB7550) at dilution of 1:200 (40x lens). |
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