Anti-CYP26B1 Antibody (CAB12142)
- SKU:
- CAB12142
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-CYP26B1 Antibody |
| 抗体コード: | CAB12142 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 213-512 of human CYP26B1 (NP_063938.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | MCF7, Mouse lung |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 213-512 of human CYP26B1 (NP_063938.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VYQQ FVDN VFSL PVDL PFSG YRRG IQAR QILQ KGLE KAIR EKLQ CTQG KDYL DALD LLIE SSKE HGKE MTMQ ELKD GTLE LIFA AYAT TASA STSL IMQL LKHP TVLE KLRD ELRA HGIL HSGG CPCE GTLR LDTL SGLR YLDC VIKE VMRL FTPI SGGY RTVL QTFE LDGF QIPK GWSV MYSI RDTH DTAP VFKD VNVF DPDR FSQA RSED KDGR FHYL PFGG GVRT CLGK HLAK LFLK VLAV ELAS TSRF ELAT RTFP RITL VPVL HPVD GLSV KFFG LDSN QNEI LPET EAML SATV |
| 遺伝子ID: | 56603 |
| Uniprot: | Q9NR63 |
| セルラーロケーション: | Endoplasmic reticulum membrane, Microsome membrane, Peripheral membrane protein |
| 計算された分子量: | 49kDa/55kDa/57kDa |
| 観察された分子量: | 58-65kDa |
| 同義語: | CYP26B1, CYP26A2, P450RAI-2, P450RAI2, RHFCA |
| バックグラウンド: | This gene encodes a member of the cytochrome P450 superfamily. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein is localized to the endoplasmic reticulum, and functions as a critical regulator of all-trans retinoic acid levels by the specific inactivation of all-trans retinoic acid to hydroxylated forms. Mutations in this gene are associated with radiohumeral fusions and other skeletal and craniofacial anomalies, and increased levels of the encoded protein are associated with atherosclerotic lesions. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | CYP26B1: Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH- RA. Esential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints. Defects in CYP26B1 are the cause of radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA). A disease characterized by craniofacial malformations, occipital encephalocele, radiohumeral fusions, oligodactyly, advanced osseous maturation, and calvarial mineralization defects. Belongs to the cytochrome P450 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell development/differentiation; Cofactor and Vitamin Metabolism - retinol; EC 1.14.-.-; Oxidoreductase Chromosomal Location of Human Ortholog: 2p13.2 Cellular Component: cytoplasm; endoplasmic reticulum membrane Molecular Function:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen; retinoic acid 4-hydroxylase activity; retinoic acid binding Biological Process: cell fate determination; embryonic limb morphogenesis; male meiosis; negative regulation of retinoic acid receptor signaling pathway; proximal/distal pattern formation; spermatogenesis; sterol metabolic process; vitamin metabolic process; xenobiotic metabolic process Disease: Radiohumeral Fusions With Other Skeletal And Craniofacial Anomalies |
| NCBI Summary: | This gene encodes a member of the cytochrome P450 superfamily. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein is localized to the endoplasmic reticulum, and functions as a critical regulator of all-trans retinoic acid levels by the specific inactivation of all-trans retinoic acid to hydroxylated forms. Mutations in this gene are associated with radiohumeral fusions and other skeletal and craniofacial anomalies, and increased levels of the encoded protein are associated with atherosclerotic lesions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013] |
| UniProt Code: | Q9NR63 |
| NCBI GenInfo Identifier: | 20137526 |
| NCBI Gene ID: | 56603 |
| NCBI Accession: | Q9NR63.1 |
| UniProt Secondary Accession: | Q9NR63,Q32MC0, Q53TW1, Q9NP41, B2R8M7, B7Z2K6, B7Z2P4 B7Z3B8, E4W5W7, |
| UniProt Related Accession: | Q9NR63 |
| Molecular Weight: | 58kDa |
| NCBI Full Name: | Cytochrome P450 26B1 |
| NCBI Synonym Full Names: | cytochrome P450 family 26 subfamily B member 1 |
| NCBI Official Symbol: | CYP26B1 |
| NCBI Official Synonym Symbols: | RHFCA; CYP26A2; P450RAI2; P450RAI-2 |
| NCBI Protein Information: | cytochrome P450 26B1 |
| UniProt Protein Name: | Cytochrome P450 26B1 |
| UniProt Synonym Protein Names: | Cytochrome P450 26A2; Cytochrome P450 retinoic acid-inactivating 2; Cytochrome P450RAI-2; Retinoic acid-metabolizing cytochrome |
| Protein Family: | Cytochrome |
| UniProt Gene Name: | CYP26B1 |
 | Western blot analysis of extracts of various cell lines, using CYP26B1 antibody (CAB12142) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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