Anti-CYB5A Antibody (CAB5401)
- SKU:
- CAB5401
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-CYB5A Antibody |
抗体コード: | CAB5401 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human CYB5A (NP_683725.1). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | MCF7, A-549, HT-29, 293T, M21 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human CYB5A (NP_683725.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MAEQ SDEA VKYY TLEE IQKH NHSK STWL ILHH KVYD LTKF LEEH PGGE EVLR EQAG GDAT ENFE DVGH STDA REMS KTFI IGEL HPDD RPKL NKPP ETLI |
遺伝子ID: | 1528 |
Uniprot: | P00167 |
セルラーロケーション: | Cytoplasm, Cytoplasmic side, Endoplasmic reticulum membrane, Microsome membrane, Single-pass membrane protein |
計算された分子量: | 11kDa/14kDa/15kDa |
観察された分子量: | 17kDa |
同義語: | CYB5A, CYB5, MCB5 |
バックグラウンド: | The protein encoded by this gene is a membrane-bound cytochrome that reduces ferric hemoglobin (methemoglobin) to ferrous hemoglobin, which is required for stearyl-CoA-desaturase activity. Defects in this gene are a cause of type IV hereditary methemoglobinemia. Three transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | CYB5A: Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases. Defects in CYB5A are the cause of methemoglobinemia CYB5A-related (METHB-CYB5A). A form of methemoglobinemia, a hematologic disease characterized by the presence of excessive amounts of methemoglobin in blood cells, resulting in decreased oxygen carrying capacity of the blood, cyanosis and hypoxia. Belongs to the cytochrome b5 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 18q23 Cellular Component: endoplasmic reticulum membrane; mitochondrial outer membrane; membrane; integral to membrane Molecular Function:cytochrome-c oxidase activity; enzyme binding; metal ion binding; aldo-keto reductase activity; heme binding Biological Process: vitamin metabolic process; response to cadmium ion; L-ascorbic acid metabolic process; water-soluble vitamin metabolic process Disease: Methemoglobinemia Type Iv |
NCBI Summary: | The protein encoded by this gene is a membrane-bound cytochrome that reduces ferric hemoglobin (methemoglobin) to ferrous hemoglobin, which is required for stearyl-CoA-desaturase activity. Defects in this gene are a cause of type IV hereditary methemoglobinemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] |
UniProt Code: | P00167 |
NCBI GenInfo Identifier: | 117809 |
NCBI Gene ID: | 1528 |
NCBI Accession: | P00167.2 |
UniProt Secondary Accession: | P00167,Q6IB14, A8MV91, F8WEU4, |
UniProt Related Accession: | P00167 |
Molecular Weight: | 14,169 Da |
NCBI Full Name: | Cytochrome b5 |
NCBI Synonym Full Names: | cytochrome b5 type A (microsomal) |
NCBI Official Symbol: | CYB5A |
NCBI Official Synonym Symbols: | CYB5; MCB5 |
NCBI Protein Information: | cytochrome b5; type 1 cyt-b5 |
UniProt Protein Name: | Cytochrome b5 |
UniProt Synonym Protein Names: | Microsomal cytochrome b5 type A; MCB5 |
Protein Family: | Cytochrome |
UniProt Gene Name: | CYB5A |
UniProt Entry Name: | CYB5_HUMAN |
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