Anti-CXXC4 Antibody (CAB7837)
- SKU:
- CAB7837
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-CXXC4 Antibody |
| 抗体コード: | CAB7837 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-198 of human CXXC4 (NP_079488.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-198 of human CXXC4 (NP_079488.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MNTN VCVE PGPS PEAP GLPK ESHL PEGA LNSL VDYN SEME RYRS FATS FYKT NGGA FPQA AKIA RITT PIFP SSAA AAAA AARI GMSP WNCD NAAT AAAA TAML WGSG GGGG GGGG GGGG GGGG GGGG GGGG GGRK SSSA AASS SASS SSAI LPAG GGGG GGGG GSRT SMHH RNDS QRLG KAGC PPEP SLQM ANTN FL |
| 遺伝子ID: | 80319 |
| Uniprot: | Q9H2H0 |
| セルラーロケーション: | Cytoplasm |
| 計算された分子量: | 20kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | CXXC4, IDAX |
| バックグラウンド: | This gene encodes a CXXC-type zinc finger domain-containing protein that functions as an antagonist of the canonical wingless/integrated signaling pathway. The encoded protein negatively regulates wingless/integrated signaling through interaction with the post synaptic density protein/ Drosophila disc large tumor suppressor/ zonula occludens-1 protein domain of Dishevelled, a scaffolding protein required for the stabilization of the transcriptional co-activator beta-catenin. In addition, the CXXC domain of this protein has been shown to bind unmethylated CpG dinucleotides, localize to promoters and CpG islands, and interact with the catalytic domain of methylcytosine dioxygenase ten-eleven-translocation 2, an iron and alpha-ketoglutarate-dependent dioxygenase that modifies the methylation status of DNA. In humans, a mutation in this gene has been associated with development of malignant renal cell carcinoma. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | CXXC4: Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1. |
| UniProt Protein Details: | Protein type:Inhibitor Chromosomal Location of Human Ortholog: 4q24 Cellular Component: cytoplasm; cytoplasmic membrane-bound vesicle; cytoplasmic vesicle Molecular Function:DNA binding; zinc ion binding; PDZ domain binding Biological Process: zygotic determination of dorsal/ventral axis; negative regulation of Wnt receptor signaling pathway; Wnt receptor signaling pathway |
| UniProt Code: | Q9H2H0 |
| NCBI GenInfo Identifier: | 74752605 |
| NCBI Gene ID: | 80319 |
| NCBI Accession: | Q9H2H0.1 |
| UniProt Related Accession: | Q9H2H0 |
| Molecular Weight: | 20,978 Da |
| NCBI Full Name: | CXXC-type zinc finger protein 4 |
| NCBI Synonym Full Names: | CXXC finger protein 4 |
| NCBI Official Symbol: | CXXC4 |
| NCBI Official Synonym Symbols: | IDAX |
| NCBI Protein Information: | CXXC-type zinc finger protein 4; CXXC finger 4; inhibition of the Dvl and axin complex protein; Dvl-binding protein IDAX (inhibition of the Dvl and Axin complex) |
| UniProt Protein Name: | CXXC-type zinc finger protein 4 |
| UniProt Synonym Protein Names: | Inhibition of the Dvl and axin complex protein |
| Protein Family: | CXXC-type zinc finger protein |
| UniProt Gene Name: | CXXC4 |
| UniProt Entry Name: | CXXC4_HUMAN |
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